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IR@PKUHSC  > 北京大学第一临床医学院  > 神经内科  > 期刊论文
学科主题: 临床医学
题名:
Miller Fisher syndrome: toward a more comprehensive understanding
作者: Li, HF1; Yuan, JM1
关键词: Miller Fisher syndrome ; GQ1b antibody ; Guillain-Barre syndrome
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-03-01
卷: 114, 期:3, 页:235-239
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GUILLAIN-BARRE-SYNDROME ; IGG ANTI-GQ(1B) ANTIBODY ; CAMPYLOBACTER-JEJUNI ; OPTIC NEUROPATHY ; GANGLIOSIDE ; OPHTHALMOPLEGIA ; IMMUNOGLOBULIN ; GQ1B ; INFECTION ; SEROTYPE
英文摘要:

Purpose To review recent knowledge on the clinical features, pathology and pathophysiology, diagnosis and treatment of Miller Fisher syndrome (MFS).

Data sources Clinical and laboratory studies on MFS in the past 10 years were included.

Results A viral infection preceded neurological symptoms in 71.8% of MFS patients. Typical MFS consists of the triad of ataxia, areflexia and ophthalmoplegia. Other cranial nerves are also involved, which may overlap with limb weakness in typical Guillain-Barre syndrome (GBS). Lower cranial nerve variants of GBS, atypical MFS and ataxic neuropathies may overlap, and are thought of as variant forms of MFS. Recurrence and CNS involvement is found more frequently in MFS than in GBS. Antibody to GQ1b, a tetrasyaloganglioside (GQ1b antibody) which is found in close relation to ophthalmoplegia in MFS, is also associated with Campylobacter jejuni (C. jejuni) serotype Penner 2. This suggests that C. jejuni may induce MFS via the GQ1b structure. The GQ1b antibody may lead to the failure of acetylcholine release from motor nerve terminals, which has been confirmed by clinical neurophysiological results.

Conclusions Many studies have shown similarities in the pathogenesis of MFS and GBS. However, there are still some differences between them, especially in the areas of sensory and CNS involvement. The GQ1b antibody is thought of as one of the key factors in the pathogenesis of MFS, especially with ophthalmoplegia, and it may prove a useful clinical marker in the diagnosis of MFS.

语种: 英语
WOS记录号: WOS:000167547000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50624
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Qingdao Univ, Affiliated Hosp Med Coll, Dept Neurol, Qingdao 266003, Peoples R China
2.Beijing Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Li, HF,Yuan, JM. Miller Fisher syndrome: toward a more comprehensive understanding[J]. CHINESE MEDICAL JOURNAL,2001,114(3):235-239.
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