IR@PKUHSC  > 北京大学第一临床医学院  > 神经内科
学科主题临床医学
Miller Fisher syndrome: toward a more comprehensive understanding
Li, HF1; Yuan, JM1
关键词Miller Fisher Syndrome Gq1b Antibody Guillain-barre Syndrome
刊名CHINESE MEDICAL JOURNAL
2001-03-01
114期:3页:235-239
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GUILLAIN-BARRE-SYNDROME ; IGG ANTI-GQ(1B) ANTIBODY ; CAMPYLOBACTER-JEJUNI ; OPTIC NEUROPATHY ; GANGLIOSIDE ; OPHTHALMOPLEGIA ; IMMUNOGLOBULIN ; GQ1B ; INFECTION ; SEROTYPE
英文摘要

Purpose To review recent knowledge on the clinical features, pathology and pathophysiology, diagnosis and treatment of Miller Fisher syndrome (MFS).

Data sources Clinical and laboratory studies on MFS in the past 10 years were included.

Results A viral infection preceded neurological symptoms in 71.8% of MFS patients. Typical MFS consists of the triad of ataxia, areflexia and ophthalmoplegia. Other cranial nerves are also involved, which may overlap with limb weakness in typical Guillain-Barre syndrome (GBS). Lower cranial nerve variants of GBS, atypical MFS and ataxic neuropathies may overlap, and are thought of as variant forms of MFS. Recurrence and CNS involvement is found more frequently in MFS than in GBS. Antibody to GQ1b, a tetrasyaloganglioside (GQ1b antibody) which is found in close relation to ophthalmoplegia in MFS, is also associated with Campylobacter jejuni (C. jejuni) serotype Penner 2. This suggests that C. jejuni may induce MFS via the GQ1b structure. The GQ1b antibody may lead to the failure of acetylcholine release from motor nerve terminals, which has been confirmed by clinical neurophysiological results.

Conclusions Many studies have shown similarities in the pathogenesis of MFS and GBS. However, there are still some differences between them, especially in the areas of sensory and CNS involvement. The GQ1b antibody is thought of as one of the key factors in the pathogenesis of MFS, especially with ophthalmoplegia, and it may prove a useful clinical marker in the diagnosis of MFS.

语种英语
WOS记录号WOS:000167547000002
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50624
Collection北京大学第一临床医学院_神经内科
作者单位1.Qingdao Univ, Affiliated Hosp Med Coll, Dept Neurol, Qingdao 266003, Peoples R China
2.Beijing Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Li, HF,Yuan, JM. Miller Fisher syndrome: toward a more comprehensive understanding[J]. CHINESE MEDICAL JOURNAL,2001,114(3):235-239.
APA Li, HF,&Yuan, JM.(2001).Miller Fisher syndrome: toward a more comprehensive understanding.CHINESE MEDICAL JOURNAL,114(3),235-239.
MLA Li, HF,et al."Miller Fisher syndrome: toward a more comprehensive understanding".CHINESE MEDICAL JOURNAL 114.3(2001):235-239.
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