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Placental concentrations of manganese and the risk of fetal neural tube defects
Liu, Jufen1,2; Jin, Lei1,2; Zhang, Le1,2; Li, Zhiwen1,2; Wang, Linlin1,2; Ye, Rongwei1,2; Zhang, Yali1,2; Ren, Aiguo1,2
关键词Neural Tube Defect Placenta Manganese Zinc Iron
刊名JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
2013
DOI10.1016/j.jtemb.2013.04.001
27期:4页:322-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]BLOOD MANGANESE ; CORD BLOOD ; IN-VITRO ; HYPERMANGANESEMIA ; POLYCYTHEMIA ; EXPRESSION ; POLLUTANTS ; MUTATIONS ; PREGNANCY ; DYSTONIA
英文摘要

Manganese (Mn) is an essential trace element required for normal growth, development, and cellular homeostasis, but excess Mn is toxic to the central nervous system. The present pilot study examined whether the level of Mn in the placenta was associated with the risk of fetal neural tube defects (NTDs). A case-control study was conducted. Cases were 80 fetuses or newborns with NTDs, and controls were 50 healthy, nonmalformed newborns. Placental Mn, zinc, copper, iron, and selenium were determined with inductively coupled plasma-mass spectrometry. The median Mn concentration was significantly higher in case placentas than in controls: cases, 131.60 ng/g (95% confidence interval [CI], 99.25-166.76); controls, 101.54 ng/g (95% CI, 80.14-119.79). Mn concentrations above the median were associated with a 4-fold (95% CI, 1.23-14.79) increased risk for any NTDs and a 7-fold (95% CI, 1.52-39.64) increased risk for spina bifida after other confounding factors were controlled. Elevated Mn levels were associated with an increased risk of anencephaly, although the adjusted odds ratio did not reach statistical significance. The association between higher Mn concentrations and risk of NTDs showed a clear dose-response relationship. Risk of NTDs increased to 1.51 (95% CI, 0.65-3.52) and 5.03 (95% CI, 1.89-13.33) for those whose placental Mn level was in the second and third tertiles, respectively, compared with the lowest tertile. Elevated placental concentrations of Mn may be associated with increased risks of NTDs in this population. (C) 2013 Elsevier GmbH. All rights reserved.

语种英语
WOS记录号WOS:000326998900010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50631
专题北京大学公共卫生学院_北京大学生育健康研究所
北京大学医学部管理机构_医学部
北京大学公共卫生学院_卫计委生育健康重点实验室
作者单位1.Peking Univ, Key Lab Reprod Hlth, Minist Hlth, Inst Reprod & Child Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jufen,Jin, Lei,Zhang, Le,et al. Placental concentrations of manganese and the risk of fetal neural tube defects[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2013,27(4):322-325.
APA Liu, Jufen.,Jin, Lei.,Zhang, Le.,Li, Zhiwen.,Wang, Linlin.,...&Ren, Aiguo.(2013).Placental concentrations of manganese and the risk of fetal neural tube defects.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,27(4),322-325.
MLA Liu, Jufen,et al."Placental concentrations of manganese and the risk of fetal neural tube defects".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 27.4(2013):322-325.
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