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学科主题: 基础医学
题名:
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
作者: Wang, Y1; Zhang, YM1; Yang, X1; Han, WL1; Liu, YN1; Xu, QM1; Zhao, R1; Di, CH1; Song, QS1; Ma, DL1
关键词: chemokine ; CLF ; recombinant CKLF1 ; TARC/CCL17 ; CCR4 ; ligand
刊名: LIFE SCIENCES
发表日期: 2006-01-02
DOI: 10.1016/j.lfs.2005.05.070
卷: 78, 期:6, 页:614-621
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: MACROPHAGE-DERIVED CHEMOKINE ; RETRACTED ARTICLE. SEE ; SMOOTH-MUSCLE-CELLS ; CYTOSKELETON REORGANIZATION ; MOLECULAR-CLONING ; SIGNALING PATHWAYS ; INDUCE CHEMOTAXIS ; RECEPTOR 4 ; PROTEIN ; INFLAMMATION
英文摘要:

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000234670600009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50637
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Y,Zhang, YM,Yang, X,et al. Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)[J]. LIFE SCIENCES,2006,78(6):614-621.
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