学科主题基础医学
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
Wang, Y1; Zhang, YM1; Yang, X1; Han, WL1; Liu, YN1; Xu, QM1; Zhao, R1; Di, CH1; Song, QS1; Ma, DL1
关键词chemokine CLF recombinant CKLF1 TARC/CCL17 CCR4 ligand
刊名LIFE SCIENCES
2006-01-02
DOI10.1016/j.lfs.2005.05.070
78期:6页:614-621
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]MACROPHAGE-DERIVED CHEMOKINE ; RETRACTED ARTICLE. SEE ; SMOOTH-MUSCLE-CELLS ; CYTOSKELETON REORGANIZATION ; MOLECULAR-CLONING ; SIGNALING PATHWAYS ; INDUCE CHEMOTAXIS ; RECEPTOR 4 ; PROTEIN ; INFLAMMATION
英文摘要

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000234670600009
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50637
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学基础医学院
北京大学第一临床医学院_急诊科
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Wang, Y,Zhang, YM,Yang, X,et al. Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)[J]. LIFE SCIENCES,2006,78(6):614-621.
APA Wang, Y.,Zhang, YM.,Yang, X.,Han, WL.,Liu, YN.,...&Ma, DL.(2006).Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).LIFE SCIENCES,78(6),614-621.
MLA Wang, Y,et al."Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)".LIFE SCIENCES 78.6(2006):614-621.
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