IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
SATB1 Expression Is Associated with Biologic Behavior in Colorectal Carcinoma In Vitro and In Vivo
Zhang, Jie1; Zhang, Baogang2; Zhang, Xumei3; Sun, Yingui4; Wei, Xiaolong5; McNutt, Michael A.6; Lu, Shijun2; Liu, Yuqing2; Zhang, Donghong7,8; Wang, Mingyu9; Lin, Zhijuan10; Niu, Na2
刊名PLOS ONE
2013-01-11
DOI10.1371/journal.pone.0047902
8期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CLINICOPATHOLOGICAL FEATURES ; CELL-PROLIFERATION ; SERRATED POLYPS ; DNA METHYLATION ; GENE-EXPRESSION ; MOLECULAR-BASIS ; CANCER ; GROWTH ; MUTATIONS ; PROTEIN
英文摘要

There is increasing evidence that Special AT-rich sequence-binding protein 1 (SATB1) is aberrantly expressed in several cancers and is correlated with clinicopathologic parameters in these tumors. In this study, we showed over-expression of SATB1 in 80 cases of colorectal cancer and in 3 colorectal cancer cell lines and found expression levels were strongly associated with tumor differentiation and stage. Expression levels of SATB1 protein were higher in poorly-differentiated as compared with well-differentiated cell lines, and both quantity and distribution patterns of SATB1 were associated with tumor differentiation and pTNM stage. Strikingly, we further investigated the effect of down regulation of SATB1 expression on malignant phenotypic features in colorectal cancer cells in vitro, and showed that SABT1 down-regulation negatively affected growth potential, anchorage-independent colony formation and cancer cell invasion, and resulted in increased apoptosis. SATB1 expression was positively associated with the expression of various biological and genetic markers, including Cyclin D1, MMP-2, NF-kappa B, and PCNA, and was associated with loss of APC and BRAF(V600E). These findings suggest that SATB1 is involved in the carcinogenesis, development and progression of colorectal cancer.

语种英语
所属项目编号BS2011SW051 ; 2010BSB14050 ; 81100885 ; 81072068
资助者Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China ; Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China
WOS记录号WOS:000314705800003
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50638
专题北京大学基础医学院_病理学系
作者单位1.Weifang Med Univ, Dept Human Anat, Weifang, Peoples R China
2.Weifang Med Univ, Dept Pathol, Weifang, Peoples R China
3.Weifang Med Univ, Affiliated Hosp, Dept Pathol, Weifang, Peoples R China
4.Weifang Med Univ, Dept Anesthesia, Weifang, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China
6.Weifang Med Univ, Dept Neurol, Weifang, Peoples R China
7.Weifang Med Univ, Univ Shandong Prov, Key Lab Immunol, Weifang, Peoples R China
8.Shantou Univ, Coll Med, Canc Hosp, Dept Pathol, Shantou, Peoples R China
9.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
10.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jie,Zhang, Baogang,Zhang, Xumei,et al. SATB1 Expression Is Associated with Biologic Behavior in Colorectal Carcinoma In Vitro and In Vivo[J]. PLOS ONE,2013,8(1).
APA Zhang, Jie.,Zhang, Baogang.,Zhang, Xumei.,Sun, Yingui.,Wei, Xiaolong.,...&Niu, Na.(2013).SATB1 Expression Is Associated with Biologic Behavior in Colorectal Carcinoma In Vitro and In Vivo.PLOS ONE,8(1).
MLA Zhang, Jie,et al."SATB1 Expression Is Associated with Biologic Behavior in Colorectal Carcinoma In Vitro and In Vivo".PLOS ONE 8.1(2013).
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