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学科主题: 基础医学
题名:
SATB1 Expression Is Associated with Biologic Behavior in Colorectal Carcinoma In Vitro and In Vivo
作者: Zhang, Jie1; Zhang, Baogang2; Zhang, Xumei3; Sun, Yingui4; Wei, Xiaolong5; McNutt, Michael A.6; Lu, Shijun2; Liu, Yuqing2; Zhang, Donghong7,8; Wang, Mingyu9; Lin, Zhijuan10; Niu, Na2
刊名: PLOS ONE
发表日期: 2013-01-11
DOI: 10.1371/journal.pone.0047902
卷: 8, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CLINICOPATHOLOGICAL FEATURES ; CELL-PROLIFERATION ; SERRATED POLYPS ; DNA METHYLATION ; GENE-EXPRESSION ; MOLECULAR-BASIS ; CANCER ; GROWTH ; MUTATIONS ; PROTEIN
英文摘要:

There is increasing evidence that Special AT-rich sequence-binding protein 1 (SATB1) is aberrantly expressed in several cancers and is correlated with clinicopathologic parameters in these tumors. In this study, we showed over-expression of SATB1 in 80 cases of colorectal cancer and in 3 colorectal cancer cell lines and found expression levels were strongly associated with tumor differentiation and stage. Expression levels of SATB1 protein were higher in poorly-differentiated as compared with well-differentiated cell lines, and both quantity and distribution patterns of SATB1 were associated with tumor differentiation and pTNM stage. Strikingly, we further investigated the effect of down regulation of SATB1 expression on malignant phenotypic features in colorectal cancer cells in vitro, and showed that SABT1 down-regulation negatively affected growth potential, anchorage-independent colony formation and cancer cell invasion, and resulted in increased apoptosis. SATB1 expression was positively associated with the expression of various biological and genetic markers, including Cyclin D1, MMP-2, NF-kappa B, and PCNA, and was associated with loss of APC and BRAF(V600E). These findings suggest that SATB1 is involved in the carcinogenesis, development and progression of colorectal cancer.

语种: 英语
所属项目编号: BS2011SW051 ; 2010BSB14050 ; 81100885 ; 81072068
项目资助者: Young and Middle-Aged Scientists Research Awards Fundation of Shandong Province ; National Natural Science Foundation of China
WOS记录号: WOS:000314705800003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50638
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Weifang Med Univ, Dept Human Anat, Weifang, Peoples R China
2.Weifang Med Univ, Dept Pathol, Weifang, Peoples R China
3.Weifang Med Univ, Affiliated Hosp, Dept Pathol, Weifang, Peoples R China
4.Weifang Med Univ, Dept Anesthesia, Weifang, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China
6.Weifang Med Univ, Dept Neurol, Weifang, Peoples R China
7.Weifang Med Univ, Univ Shandong Prov, Key Lab Immunol, Weifang, Peoples R China
8.Shantou Univ, Coll Med, Canc Hosp, Dept Pathol, Shantou, Peoples R China
9.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
10.Beijing Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China

Recommended Citation:
Zhang, Jie,Zhang, Baogang,Zhang, Xumei,et al. SATB1 Expression Is Associated with Biologic Behavior in Colorectal Carcinoma In Vitro and In Vivo[J]. PLOS ONE,2013,8(1).
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