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学科主题: 临床医学
题名:
Evaluation of syphilis serostatus on the safety of IVF treatment
作者: Lin, Shengli1,2,3; Li, Rong1,2,3; Huang, Shuo1,2,3; Zhao, Lianming4; Li, Ming1,2,3; Li, Junsheng1,2,3; Zhu, Jinliang1,2,3; Zheng, Xiaoying1,2,3; Huang, Jin1,2,3; Liu, Ping1,2,3; Qiao, Jie1,2,3
关键词: IVF-ET ; syphilis serostatus ; pregnancy outcomes
刊名: REPRODUCTIVE BIOMEDICINE ONLINE
发表日期: 2014-12-01
DOI: 10.1016/j.rbmo.2014.09.001
卷: 29, 期:6, 页:756-760
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: MATERNAL SYPHILIS ; CULTURE-MEDIA ; PREGNANCY ; GUIDELINES ; EMBRYOS
英文摘要:

An increasing number of infertile syphilis-infected individuals have turned to assisted reproductive technology; however, the safety of syphilis carrier serostatus on IVF and embryo transfer outcomes has not been evaluated. Data from 482 patients who delivered singletons were analysed. In the retrospective study, the rate of IVF and intracytoplasmic sperm injection fertilization was 79.50% +/- 17.57%/ 78.72% +/- 16.66% in the Treponema pallidum particle agglutination assay negative (TPPA-negative) and rapid plasma reagin negative (RPR-negative) group, 76.12% +/- 22.99%/ 74.05% +/- 20.31% in the TPPA-positive and RPR-negative group, and 75.66% +/- 21.72%/ 70.90% +/- 16.11% in the TPPA-positive and RPR-positive group. The clinical pregnancy rate was 39.79% in the TPPAnegative and RPR-negative group, 46.30% in the TPPA-positive and RPR-negative group, and 36.59% in the TPPA-positive and RPR-positive group. No significant differences were found between the groups. The neonatal gestational age and mean birth weight were not significantly different between the TPPA-negative and TPPA-positive groups. Multiple linear regression analysis also showed no association between TPPA serostatus and newborn birth weight and gestational age. The present retrospective study showed that TPPA and RPR serostatus did not affect the outcomes of IVF and embryo transfer. Syphilis-infected individuals can undergo IVF and embryo transfer cycles after penicillin treatment. (C) 2014 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.

语种: 英语
所属项目编号: 81200437 ; 81200413 ; 81100466
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000345759300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50639
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Dept Obstet & Gynecol, Reprod Med Ctr, Hosp 3, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China

Recommended Citation:
Lin, Shengli,Li, Rong,Huang, Shuo,et al. Evaluation of syphilis serostatus on the safety of IVF treatment[J]. REPRODUCTIVE BIOMEDICINE ONLINE,2014,29(6):756-760.
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