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学科主题: 临床医学
题名:
Effect of Recombinant Adenovirus-p53 Combined With Radiotherapy on Long-Term Prognosis of Advanced Nasopharyngeal Carcinoma
作者: Pan, Jian-ji1; Zhang, Shan-wen1; Chen, Chuan-beng1; Xiao, Shao-wen1; Sun, Yan1; Liu, Chang-qin1; Su, Xing1; Li, Dong-ming1; Xu, Gang1; Xu, Bo1; Lu, You-yong1
刊名: JOURNAL OF CLINICAL ONCOLOGY
发表日期: 2009-02-10
DOI: 10.1200/JCO.2008.18.9670
卷: 27, 期:5, 页:799-804
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: WILD-TYPE P53 ; SQUAMOUS-CELL CARCINOMA ; GENE-TRANSFER ; LUNG-CANCER ; IN-VIVO ; THERAPY ; EXPRESSION ; HEAD ; ANGIOGENESIS ; MUTATIONS
英文摘要:

Purpose

To centrally assess the safety, efficacy, and 6-year follow-up of recombinant adenovirus-p53 (rAd-p53) combined with radiotherapy (RT) for patients with nasopharyngeal carcinoma (NPC).

Patients and Methods

A randomized controlled clinical study on rAd-p53 combined with RT in 42 patients with NPC was compared with a control group of 40 patients with NPC treated with RT alone. In the group receiving rAd-p53 combined with RT, rAd-p53 was intratumorally injected once a week for 8 weeks. Concurrent RT (70 Gy in 35 fractions) was given to the nasopharyngeal tumor and neck lymph node. Patients and tumors were monitored for adverse events and responses.

Results

rAd-p53-specific p53 mRNA was detected in postinjection of rAd-p53 biopsies from 16 (94.1%) of 17 patients. Upregulation of p21/WAF1 and Bax and downregulation of vascular endothelial growth factor were observed in postinjection tumor biopsy. Complete response rate in the group receiving rAd-p53 combined with RT was observed at 2.73 times that of the group receiving RT alone (66.7% v 24.4%). Six-year follow-up data showed that rAd-p53 significantly increased the 5-year locoregional tumor control rate by 25.3% for patients with NPC treated with irradiation (P = .002). The 5-year overall survival rate and 5-year disease-free survival rate of the group receiving rAd-p53 combined with RT were 7.5% (P = .34) and 11.7% (P = .21) higher than those of the group receiving RT alone. No dose-limiting toxicity or adverse events appeared, except for transient fever after rAd-p53 administration.

Conclusion

In patients with NPC, rAd-p53 was safe and biologically active. Our results indicated that rAd-p53 improves radiotherapeutic tumor control and survival rate in patients with NPC.

语种: 英语
项目资助者: National Science Committee
WOS记录号: WOS:000263139800022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50640
Appears in Collections:北京大学临床肿瘤学院_医学影像科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Radiotherapy, Beijing 100036, Peoples R China
2.Fujian Prov Canc Hosp, Fuzhou, Peoples R China

Recommended Citation:
Pan, Jian-ji,Zhang, Shan-wen,Chen, Chuan-beng,et al. Effect of Recombinant Adenovirus-p53 Combined With Radiotherapy on Long-Term Prognosis of Advanced Nasopharyngeal Carcinoma[J]. JOURNAL OF CLINICAL ONCOLOGY,2009,27(5):799-804.
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