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学科主题: 药学
题名:
Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.
作者: Song, Yue-Lin; Zeng, Ke-Wu; Shi, Tian-Xing; Jiang, Yong; Tu, Peng-Fei
关键词: Polygala sibirica ; Aerial parts ; Triterpenoid saponins ; Anti-ischemic effect
刊名: FITOTERAPIA
发表日期: 2013
DOI: 10.1016/j.fitote.2012.12.017
卷: 84, 页:295-301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ROOTS ; TENUIFOLIA ; JAPONICA ; WILLD
英文摘要:

Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3 beta,19 alpha-dihydroxyurso-12-ene-23,28-dioic acid 3-O-beta-D-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-alpha-L-arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-beta-D-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-alpha-L-arabinopyranoside (4), and 3-O-beta-D-glucopyranosyl medicagenic acid 28-O-beta-D-galactopyranosyl (1 -> 4)-beta-D-xylopyranosyl (1 -> 4)-alpha-L-rhamnopyranosyl (1 -> 2)-(4-O-acetyl)-[beta-D-apiofuranosyl (1 -> 3)]-beta-D-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC50 value of 46.7 mu M. (c) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012ZX09301002-002-002 ; 2012ZX09304-005 ; 985-2-102-113 ; 2012M510294 ; 30873429
项目资助者: National Key Technology R&amp ; D Program "New Drug Innovation" of China ; New-Century Talent Program, Ministry of Education of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China
WOS记录号: WOS:000316531400041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50641
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Song, Yue-Lin,Zeng, Ke-Wu,Shi, Tian-Xing,et al. Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.[J]. FITOTERAPIA,2013,84:295-301.
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