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学科主题: 临床医学
题名:
TIME-DEPENDENT ASSOCIATIONS BETWEEN TOTAL SODIUM REMOVAL AND MORTALITY IN PATIENTS ON PERITONEAL DIALYSIS
作者: Dong, Jie1,2,3; Li, Yanjun1,2,3; Yang, Zhikai1,2,3; Luo, Jianfeng4; Zuo, Li1,2,3
关键词: Sodium ; fluid ; nutrition ; mortality
刊名: PERITONEAL DIALYSIS INTERNATIONAL
发表日期: 2011-07-01
DOI: 10.3747/pdi.2010.00103
卷: 31, 期:4, 页:412-421
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: EXTRACELLULAR VOLUME EXPANSION ; FLUID REMOVAL ; TRANSPORT CHARACTERISTICS ; NUTRITIONAL-STATUS ; WATER REMOVAL ; BODY-MASS ; ADEQUACY ; MEMBRANE ; SOLUTE ; SALT
英文摘要:

Purpose: To determine if the time-dependent association between total sodium removal and mortality in patients on continuous ambulatory peritoneal dialysis (CAPD) is confounded by markers of diet and nutrition.

Methods: The study enrolled 305 incident patients who started CAPD between July 2002 and February 2007. All patients were followed until death or censoring in February 2008. Demographics, blood pressure, and markers of volume and inflammation were collected at baseline. Biochemistry, fluid and solute removal, and diet and nutrition parameters were collected quarterly and thus calculated as time-averaged values.

Results: Mean age of the study patients was 59.4 years, 42.3% were men, and 40.3% had diabetes. During the 31.4-month follow-up, 74 patients died. The time-averaged daily total sodium removal (TSR) in the overall cohort was 2.67 g (range: 2.02 g - 3.47 g). Participants with a high time-averaged TSR tended to experience higher fluid, sodium, urea, and creatinine removal, mainly as a result of better residual renal function (RRF). They also had a higher nutrient intake and a higher lean body mass. Time-dependent TSR was an independent predictor of death, including when adjusted for age, Charlson index, time-dependent hemoglobin, RRF, and peritoneal transport rate (hazard ratio: 0.84; 95% confidence interval: 0.70 to 1.00; p = 0.05), but the predictive effect disappeared in multivariate models after further individual adjustment for time-dependent total energy intake, total protein intake, serum albumin, and lean body mass. By contrast, the predictive effect did not disappear if the only adjustment was for time-dependent RRF.

Conclusions: The time-dependent association between TSR and mortality in patients on peritoneal dialysis can be largely explained by diet and nutrition parameters.

语种: 英语
WOS记录号: WOS:000293229800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50643
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
3.Peking Univ, Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
4.Fudan Univ, Sch Publ Hlth, Dept Hlth Stat & Social Med, Shanghai 200433, Peoples R China

Recommended Citation:
Dong, Jie,Li, Yanjun,Yang, Zhikai,et al. TIME-DEPENDENT ASSOCIATIONS BETWEEN TOTAL SODIUM REMOVAL AND MORTALITY IN PATIENTS ON PERITONEAL DIALYSIS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2011,31(4):412-421.
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