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学科主题: 临床医学
题名:
Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis
作者: Zhao, Yi1; Tian, Xin1; Li, Zhanguo1
关键词: citrullination ; fibrinogen ; rheumatoid arthritis
刊名: CLINICAL RHEUMATOLOGY
发表日期: 2007-09-01
DOI: 10.1007/s10067-007-0544-y
卷: 26, 期:9, 页:1505-1512
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: DIAGNOSTIC-VALUE ; ANTIFILAGGRIN AUTOANTIBODIES ; ANTIKERATIN ANTIBODIES ; REVISED CRITERIA ; PEPTIDE ; CLASSIFICATION ; FILAGGRIN ; DETERMINANTS ; PERFORMANCE ; DISEASE
英文摘要:

It has been reported that citrullinated fibrin(ogen) deposits in the inflamed joints played an important role in the pathogenesis of rheumatoid arthritis (RA). Although antibodies to citrullinated fibrinogen (ACF) have been detected in the sera of RA patients, the associations between ACF and RA remain unclear. In this study, human fibrinogen was citrullinated by peptidylarginine deiminase in vitro, and the ACF were detected by an enzyme-linked immunosorbent assay in rheumatic patients, including 183 RA, 121 systemic lupus erythematosus, 48 osteoarthritis, and 108 healthy controls. The prevalence of ACF was determined, and the associations between ACF and RA were evaluated. It was shown that the sensitivity and specificity of ACF in RA were 67.21 and 84.84%, respectively. There were significant correlations between ACF and erythrocyte sedimentation rate, anti-cyclic citrullinated peptide antibody, and anti-keratin antibodies (AKA). In radiographic progression, the RA patients with ACF had higher scores than those without ACF according to the Sharp-van der Heijde method. In addition, ACF was often positive in the RA patients who were IgM rheumatoid factor negative or AKA negative or anti-perinuclear factor negative. The results indicate that ACF assay is helpful for the diagnosis of RA.

语种: 英语
WOS记录号: WOS:000248580600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50644
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Univ, Peoples Hosp, Sch Med, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Jilin Univ, Second Hosp, Dept Pediat, Changchun 130023, Peoples R China

Recommended Citation:
Zhao, Yi,Tian, Xin,Li, Zhanguo. Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis[J]. CLINICAL RHEUMATOLOGY,2007,26(9):1505-1512.
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