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学科主题: 基础医学
题名:
Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction
作者: Wang, F1; Liu, YY1; Liu, LY1; Guo, J1; Sun, K1; Wang, CS1; Fan, JY1; Han, JY1
关键词: cardiotonic pills ; venous thrombosis ; adhesion molecules ; platelet ; videomicroscopy
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2006
卷: 34, 期:1-2, 页:131-138
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: PLATELET-AGGREGATION ; ENDOTHELIAL-CELLS ; REPERFUSION ; MICROVESSELS ; PECAM-1 ; DAMAGE ; LIGHT ; DYE
英文摘要:

This paper was aimed to explore the inhibition effect of cardiotonic pills (CP) on venous thrombosis induced in rat mesentery by photochemical stimulation (PS). Male Sprague-Dawley rats were anesthetized with urethane. Thrombosis was induced in the mesenteric venule by PS with photosensitizer hematoporphyrin and an ultraviolet beam. The rats were divided into three groups: control (n = 6), PS (n = 6) and PS + CP group (n = 6) where CP solution (0.4 g/kg.b) was administrated orally 60 min before PS. Microcirculatory disturbances in the mesentery were observed under an inverted microscope with a color video-camera. Based on the recorded images, the development of thrombosis was evaluated in term of time of thrombosis appearance (T-a) and area ratio of thrombus/vessel (AR). The expression of adhesion molecule (CD31) of platelet was examined in blood taken from the abdominal aorta, using flow cytometry. The T-a was approximately 10 seconds after PS in PS group, but it was approximately 20 seconds in PS + CP group. The AR in PS + CP group was significantly reduced, compared to that in PS group, during the period of the observation. The CD31 expression was not changed in both groups, while positive cells were significantly increased in the number. It is suggested that CP might suppress thrombus development under the interaction of platelet with endothelium.

语种: 英语
WOS记录号: WOS:000236802600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50647
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Integrated Tradit Chinese & Western Med, Beijing 100083, Peoples R China

Recommended Citation:
Wang, F,Liu, YY,Liu, LY,et al. Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2006,34(1-2):131-138.
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