学科主题基础医学
Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction
Wang, F()1; Liu, YY()1; Liu, LY()1; Guo, J()1; Sun, K()1; Wang, CS()1; Fan, JY()1; Han, JY()1
关键词Cardiotonic Pills Venous Thrombosis Adhesion Molecules Platelet Videomicroscopy
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2006
34期:1-2页:131-138
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PLATELET-AGGREGATION ; ENDOTHELIAL-CELLS ; REPERFUSION ; MICROVESSELS ; PECAM-1 ; DAMAGE ; LIGHT ; DYE
英文摘要

This paper was aimed to explore the inhibition effect of cardiotonic pills (CP) on venous thrombosis induced in rat mesentery by photochemical stimulation (PS). Male Sprague-Dawley rats were anesthetized with urethane. Thrombosis was induced in the mesenteric venule by PS with photosensitizer hematoporphyrin and an ultraviolet beam. The rats were divided into three groups: control (n = 6), PS (n = 6) and PS + CP group (n = 6) where CP solution (0.4 g/kg.b) was administrated orally 60 min before PS. Microcirculatory disturbances in the mesentery were observed under an inverted microscope with a color video-camera. Based on the recorded images, the development of thrombosis was evaluated in term of time of thrombosis appearance (T-a) and area ratio of thrombus/vessel (AR). The expression of adhesion molecule (CD31) of platelet was examined in blood taken from the abdominal aorta, using flow cytometry. The T-a was approximately 10 seconds after PS in PS group, but it was approximately 20 seconds in PS + CP group. The AR in PS + CP group was significantly reduced, compared to that in PS group, during the period of the observation. The CD31 expression was not changed in both groups, while positive cells were significantly increased in the number. It is suggested that CP might suppress thrombus development under the interaction of platelet with endothelium.

语种英语
WOS记录号WOS:000236802600018
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50647
专题北京大学基础医学院_北大医学部天士力微循环研究中心
北京大学基础医学院
北京大学临床肿瘤学院_肾癌黑色素瘤内科
作者单位1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Integrated Tradit Chinese & Western Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, F,Liu, YY,Liu, LY,et al. Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2006,34(1-2):131-138.
APA Wang, F.,Liu, YY.,Liu, LY.,Guo, J.,Sun, K.,...&Han, JY.(2006).Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,34(1-2),131-138.
MLA Wang, F,et al."Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 34.1-2(2006):131-138.
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