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The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia
Jiang, Qian; Zhao, Xiang-Yu; Qin, Ya-Zhen; Liu, Yan-Rong; Lai, Yue-Yun; Jiang, Bin; Huang, Xiao-Jun
刊名AMERICAN JOURNAL OF HEMATOLOGY
2012-12-01
DOI10.1002/ajh.23321
87期:12页:1065-1069
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]CHRONIC MYELOID-LEUKEMIA ; POLYMERASE-CHAIN-REACTION ; PATIENTS RECEIVING IMATINIB ; CHRONIC-PHASE ; RESIDUAL DISEASE ; FOLLOW-UP ; THERAPY ; CYTOGENETICS ; INTERFERON ; STI571
英文摘要

Previous studies concerning BCR-ABL mRNA levels by quantitative real-time RT-PCR (Q-PCR) for chronic myelogenous leukemia (CML) have shown a significant concordance between peripheral blood (PB) and bone marrow (BM) assays. The objective of this study was to determine whether molecular monitoring using PB was comparable to using BM for CML. A comparative study was performed that analyzed the Q-PCR results of 712 simultaneous PB and BM samples from 330 patients before and during imatinib therapy. For the 78 paired pretreatment samples, the level of BCR-ABL mRNA in PB was lower than that in BM (P = 0.007). Although the overall amounts of BCR-ABL mRNA in the PB and BM were comparable (P= 0.072) and there was a strong correlation (r = 0.839, P < 0.001) with the 634 paired on-treatment samples, the depth of the molecular response in PB was lower than that in BM (P < 0.001). The level of BCR-ABL mRNA in PB was lower than that in BM where the BM BCR-ABL mRNA < 1 log reduction (P < 0.001) or = 1< 2 log-reductions (P = 0.008) from the baseline, and higher than that where the BM BCR-ABL mRNA = 2 log-reductions (P < 0.001). A strong correlation (r = 0.811, P < 0.001) was only found where the BM BCR-ABL mRNA < 1 log reduction. We conclude that the differences and correlations of BCR-ABL mRNA between PB and BM assays depend on the depth of the molecular response in BM for CML during imatinib therapy. Am. J. Hematol., 2012. (c) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000311054700008
项目编号30971292 ; 2011AA020105
资助机构National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty by the Ministry of Health of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50649
专题北京大学第二临床医学院
北京大学药学院_药事管理与临床药学系
北京大学第二临床医学院_血液科
作者单位Peking Univ Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
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Jiang, Qian,Zhao, Xiang-Yu,Qin, Ya-Zhen,et al. The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia[J]. AMERICAN JOURNAL OF HEMATOLOGY,2012,87(12):1065-1069.
APA Jiang, Qian.,Zhao, Xiang-Yu.,Qin, Ya-Zhen.,Liu, Yan-Rong.,Lai, Yue-Yun.,...&Huang, Xiao-Jun.(2012).The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia.AMERICAN JOURNAL OF HEMATOLOGY,87(12),1065-1069.
MLA Jiang, Qian,et al."The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia".AMERICAN JOURNAL OF HEMATOLOGY 87.12(2012):1065-1069.
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