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学科主题: 临床医学
题名:
The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia
作者: Jiang, Qian; Zhao, Xiang-Yu; Qin, Ya-Zhen; Liu, Yan-Rong; Lai, Yue-Yun; Jiang, Bin; Huang, Xiao-Jun
刊名: AMERICAN JOURNAL OF HEMATOLOGY
发表日期: 2012-12-01
DOI: 10.1002/ajh.23321
卷: 87, 期:12, 页:1065-1069
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: CHRONIC MYELOID-LEUKEMIA ; POLYMERASE-CHAIN-REACTION ; PATIENTS RECEIVING IMATINIB ; CHRONIC-PHASE ; RESIDUAL DISEASE ; FOLLOW-UP ; THERAPY ; CYTOGENETICS ; INTERFERON ; STI571
英文摘要:

Previous studies concerning BCR-ABL mRNA levels by quantitative real-time RT-PCR (Q-PCR) for chronic myelogenous leukemia (CML) have shown a significant concordance between peripheral blood (PB) and bone marrow (BM) assays. The objective of this study was to determine whether molecular monitoring using PB was comparable to using BM for CML. A comparative study was performed that analyzed the Q-PCR results of 712 simultaneous PB and BM samples from 330 patients before and during imatinib therapy. For the 78 paired pretreatment samples, the level of BCR-ABL mRNA in PB was lower than that in BM (P = 0.007). Although the overall amounts of BCR-ABL mRNA in the PB and BM were comparable (P= 0.072) and there was a strong correlation (r = 0.839, P < 0.001) with the 634 paired on-treatment samples, the depth of the molecular response in PB was lower than that in BM (P < 0.001). The level of BCR-ABL mRNA in PB was lower than that in BM where the BM BCR-ABL mRNA < 1 log reduction (P < 0.001) or = 1< 2 log-reductions (P = 0.008) from the baseline, and higher than that where the BM BCR-ABL mRNA = 2 log-reductions (P < 0.001). A strong correlation (r = 0.811, P < 0.001) was only found where the BM BCR-ABL mRNA < 1 log reduction. We conclude that the differences and correlations of BCR-ABL mRNA between PB and BM assays depend on the depth of the molecular response in BM for CML during imatinib therapy. Am. J. Hematol., 2012. (c) 2012 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 30971292 ; 2011AA020105
项目资助者: National Natural Science Foundation of China ; HI-Tech Research Development Program of China 863 ; Leading Program of Clinical Faculty by the Ministry of Health of China
WOS记录号: WOS:000311054700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50649
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ Inst Hematol, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Jiang, Qian,Zhao, Xiang-Yu,Qin, Ya-Zhen,et al. The differences and correlations of BCR-ABL transcripts between peripheral blood and bone marrow assays are associated with the molecular responses in the bone marrow for chronic myelogenous leukemia[J]. AMERICAN JOURNAL OF HEMATOLOGY,2012,87(12):1065-1069.
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