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学科主题: 药学
题名:
Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats
作者: Tian, Wei2; Ying, Xue2; Du, Ju2; Guo, Jia2; Men, Ying2; Zhang, Yan2; Li, Ruo-Jing2; Yao, Hong-Juan2; Lou, Jin-Ning3; Zhang, Liang-Ren2; Lu, Wan-Liang1,2
关键词: Functionalized epirubicin liposomes ; Tamoxifen ; Transferrin ; BBB model ; Brain glioma-bearing rats
刊名: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
发表日期: 2010-10-09
DOI: 10.1016/j.ejps.2010.06.008
卷: 41, 期:2, 页:232-243
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: IN-VITRO MODEL ; CAPILLARY ENDOTHELIAL-CELLS ; BREAST-CANCER ; BLOOD-BRAIN ; DRUG-DELIVERY ; MULTIDRUG-RESISTANCE ; ANTITUMOR-ACTIVITY ; GENE DELIVERY ; MEDIATED DRUG ; SOLID TUMORS
英文摘要:

Purpose: The restriction of drug transporting across the blood-brain barrier (BBB) and the limit of drug penetrating into the tumor tissue remain the major obstacles for brain tumor chemotherapy. In the present study, we developed a functionalized liposomal nanoconstruct, epirubicin liposomes modified with tamoxifen (TAM) and transferrin (TF), for transporting drug across the BBB and afterwards targeting the brain glioma.

Methods: Evaluations were performed on the murine C6 glioma cells, the C6 glioma spheroids, the BBB model in vitro and the brain glioma-bearing rats.

Results: When compared with controls, epirubicin liposomes modified with TAM and TF showed the strongest inhibitory effect to C6 glioma cells or glioma spheroids in vitro, significant transport ability across the BBB model in vitro, an evident effect of targeting the brain tumor cells in vitro, and an extended median survival time in the brain glioma-bearing rats.

Conclusion: Epirubicin liposomes modified with TAM and TF significantly improve the therapeutic efficacy of brain glioma in vitro and in animals, hence providing a new strategy for brain tumor chemotherapy. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007CB935801 ; 20772664 ; 7091006
项目资助者: National Basic Research Program of China (973 program) ; National Science Foundation of China ; National Science Foundation of Beijing
WOS记录号: WOS:000281995200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50650
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.China Japan Friendship Hosp, Inst Clin Med Sci, Minist Hlth, Beijing, Peoples R China

Recommended Citation:
Tian, Wei,Ying, Xue,Du, Ju,et al. Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2010,41(2):232-243.
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