IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所
学科主题临床医学
Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose- derived stem cells
Hu, Xiaoqing1; Fu, Yutuo2; Zhang, Xin1; Dai, Linghui1; Zhu, Jingxian1; Bi, Zhenggang2; Ao, Yingfang1; Zhou, Chunyan3
关键词Adipose Derived Stem Cells Epigenetic Regulation Histone Deacetylase Inhibitor Osteogenic Differentiation Sodium Butyrate
刊名DEVELOPMENT GROWTH & DIFFERENTIATION
2014-04-01
DOI10.1111/dgd.12119
56期:3页:206-213
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Developmental Biology
资助者Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Sciences Foundation of China ; 111 Project of China ; China Postdoctoral Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Sciences Foundation of China ; 111 Project of China ; China Postdoctoral Science Foundation
研究领域[WOS]Cell Biology ; Developmental Biology
关键词[WOS]IN-VITRO ; RUNX2/CBFA1 ; EXPRESSION ; TISSUE ; BONE
英文摘要

Adult stem cells hold great promise for use in tissue repair and regeneration. Recently, adipose tissue-derived stem cells (ADSCs) were found to be an appealing alternative to bone marrow stem cells (BMSCs) for bone tissue engineering. The main benefit of ADSCs is that they can be easily and abundantly available from adipose tissue. However, our prior study discovered an important phenomenon that BMSCs have greater osteogenic potential than ADSCs in vitro and epigenetic regulation plays a critical role in runt-related transcription factor 2 (Runx2) expression and thus osteogenesis. In this study, we aimed to improve the osteogenic potential of ADSCs by histone deacetylase inhibitor sodium butyrate (NaBu). We found that NaBu promoted rat ADSC osteogenic differentiation by altering the epigenetic modifications on the Runx2 promoter.

语种英语
所属项目编号20110001130001 ; 90919022 ; 81101350 ; 81070112 ; 81071675 ; B07001 ; 20110490249
资助者Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Sciences Foundation of China ; 111 Project of China ; China Postdoctoral Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Sciences Foundation of China ; 111 Project of China ; China Postdoctoral Science Foundation
WOS记录号WOS:000333747300002
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50659
Collection北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Inst Sports Med, Hosp 3, Beijing 100191, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 1, Dept Orthoped, Harbin 150001, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xiaoqing,Fu, Yutuo,Zhang, Xin,et al. Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose- derived stem cells[J]. DEVELOPMENT GROWTH & DIFFERENTIATION,2014,56(3):206-213.
APA Hu, Xiaoqing.,Fu, Yutuo.,Zhang, Xin.,Dai, Linghui.,Zhu, Jingxian.,...&Zhou, Chunyan.(2014).Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose- derived stem cells.DEVELOPMENT GROWTH & DIFFERENTIATION,56(3),206-213.
MLA Hu, Xiaoqing,et al."Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose- derived stem cells".DEVELOPMENT GROWTH & DIFFERENTIATION 56.3(2014):206-213.
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