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Minimum effective local anesthetic dose of intrathecal hyperbaric ropivacaine and bupivacaine for cesarean section
Geng Zhi-yu; Wang Dong-xin; Wu Xin-min
关键词Anesthesia Obstetric Anesthetics Local Dose-response Relationship Cesarean Section Ropivacaine Anesthetic Technique Subarachnoid
刊名CHINESE MEDICAL JOURNAL
2011-02-20
DOI10.3760/cma.j.issn.0366-6999.2011.04.005
124期:4页:509-513
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]LOWER-LIMB SURGERY ; SPINAL ROPIVACAINE ; EPIDURAL BUPIVACAINE ; LEVOBUPIVACAINE ; LABOR ; POTENCIES ; PLAIN ; ANALGESIA ; DELIVERY
英文摘要

Background Intrathecal anesthesia is commonly used for cesarean section. Bupivacaine and ropivacaine have all been used as intrathecal drugs. The minimum effective local anesthetic dose (MLAD) of intrathecal ropivacaine for nonobstetric patients has been reported. However, few data are available on the MLAD of hyperbaric ropivacine for obstetric patients and the relative potency to bupivacaine has not been fully determined. In this study, we sought to determine the MLAD of intrathecal ropivacaine and bupivacaine for elective cesarean section and to define their relative potency ratio.

Methods We enrolled forty parturients undergoing elective cesarean section under combined spinal-epidural anesthesia and randomized them to one of two groups to receive intrathecal 0.5% hyperbaric ropivacaine or bupivacaine. The initial dose was 10 mg, and was increased in increments of 1 mg, using the technique of up-down sequential allocation. Efficacy was accepted if adequate sensory dermatomal anesthesia to pin prick to T7 or higher was attained within 20 minutes after intrathecal injection, and required no supplementary epidural injection for procedure until at least 50 minutes after the intrathecal injection.

Results The intrathecal MLAD was 9.45 mg (95%confidence interval (CI), 8.45-10.56 mg) for ropivacaine and 7.53 mg (95%CI, 7.00-8.10 mg) for bupivacaine. The relative potency ratio was 0.80 (95% CI, 0.74-0.85) for ropivacaine/bupivacaine when given intrathecally in cesarean section.

Conclusion Ropivacaine is 20% less potent than bupivacaine during intrathecal anesthesia for cesarean delivery. Chin Med J 2011;124(4):509-513

语种英语
WOS记录号WOS:000287992500005
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50663
专题北京大学第一临床医学院
北京大学第一临床医学院_麻醉科
作者单位Peking Univ, Dept Anesthesiol & Surg Intens Care, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Geng Zhi-yu,Wang Dong-xin,Wu Xin-min. Minimum effective local anesthetic dose of intrathecal hyperbaric ropivacaine and bupivacaine for cesarean section[J]. CHINESE MEDICAL JOURNAL,2011,124(4):509-513.
APA Geng Zhi-yu,Wang Dong-xin,&Wu Xin-min.(2011).Minimum effective local anesthetic dose of intrathecal hyperbaric ropivacaine and bupivacaine for cesarean section.CHINESE MEDICAL JOURNAL,124(4),509-513.
MLA Geng Zhi-yu,et al."Minimum effective local anesthetic dose of intrathecal hyperbaric ropivacaine and bupivacaine for cesarean section".CHINESE MEDICAL JOURNAL 124.4(2011):509-513.
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