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学科主题: 临床医学
题名:
Minimum effective local anesthetic dose of intrathecal hyperbaric ropivacaine and bupivacaine for cesarean section
作者: Geng Zhi-yu; Wang Dong-xin; Wu Xin-min
关键词: anesthesia, obstetric, cesarean section ; anesthetics local, ropivacaine ; anesthetic technique, subarachnoid ; dose-response relationship
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-02-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.04.005
卷: 124, 期:4, 页:509-513
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LOWER-LIMB SURGERY ; SPINAL ROPIVACAINE ; EPIDURAL BUPIVACAINE ; LEVOBUPIVACAINE ; LABOR ; POTENCIES ; PLAIN ; ANALGESIA ; DELIVERY
英文摘要:

Background Intrathecal anesthesia is commonly used for cesarean section. Bupivacaine and ropivacaine have all been used as intrathecal drugs. The minimum effective local anesthetic dose (MLAD) of intrathecal ropivacaine for nonobstetric patients has been reported. However, few data are available on the MLAD of hyperbaric ropivacine for obstetric patients and the relative potency to bupivacaine has not been fully determined. In this study, we sought to determine the MLAD of intrathecal ropivacaine and bupivacaine for elective cesarean section and to define their relative potency ratio.

Methods We enrolled forty parturients undergoing elective cesarean section under combined spinal-epidural anesthesia and randomized them to one of two groups to receive intrathecal 0.5% hyperbaric ropivacaine or bupivacaine. The initial dose was 10 mg, and was increased in increments of 1 mg, using the technique of up-down sequential allocation. Efficacy was accepted if adequate sensory dermatomal anesthesia to pin prick to T7 or higher was attained within 20 minutes after intrathecal injection, and required no supplementary epidural injection for procedure until at least 50 minutes after the intrathecal injection.

Results The intrathecal MLAD was 9.45 mg (95%confidence interval (CI), 8.45-10.56 mg) for ropivacaine and 7.53 mg (95%CI, 7.00-8.10 mg) for bupivacaine. The relative potency ratio was 0.80 (95% CI, 0.74-0.85) for ropivacaine/bupivacaine when given intrathecally in cesarean section.

Conclusion Ropivacaine is 20% less potent than bupivacaine during intrathecal anesthesia for cesarean delivery. Chin Med J 2011;124(4):509-513

语种: 英语
WOS记录号: WOS:000287992500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50663
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Dept Anesthesiol & Surg Intens Care, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Geng Zhi-yu,Wang Dong-xin,Wu Xin-min. Minimum effective local anesthetic dose of intrathecal hyperbaric ropivacaine and bupivacaine for cesarean section[J]. CHINESE MEDICAL JOURNAL,2011,124(4):509-513.
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