IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Expression of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in mice hair cycle
Wang, Y1; Yang, SX1; Tu, P1; Zhang, B1; Ma, SQ1
关键词Parathyroid hormone/Parathyroid Hormone-related Peptide Receptor Mice Hair Cycle
刊名JOURNAL OF DERMATOLOGICAL SCIENCE
2002-11-01
30期:2页:136-141
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]PROTEIN-KINASE-C ; IMMUNOHISTOCHEMICAL LOCALIZATION ; HUMORAL HYPERCALCEMIA ; HUMAN KERATINOCYTES ; ADENYLATE-CYCLASE ; FIBER PRODUCTION ; FOLLICLE GROWTH ; ORGAN-CULTURE ; SKIN ; IDENTIFICATION
英文摘要

There is increasing evidence that parathyroid hormone (PTH) and PTH-related peptide (PTHrP) are involved in normal skin cell growth, influence the proliferation and differentiation of the epidermis and hair follicle. PTHrP and PTH/PTHrP receptor show prominent cutaneous expression, may exert important paracrine and/or autocrine functions. The expression of PTH/PTHrP receptor in different stages of hair cycle is unknown. Therefore, we examined the amount of PTH/PTHrP mRNA in C57BL/6 mice skin at different stages of hair cycle by relatively quantitative reverse transcription-polymerase chain reaction (RT-PCR), and investigated the localization of this receptor in mice skin by in situ hybridization. The expression of PTH/PTHrP receptor mRNA were higher in anagen, but significantly lower in catagen and telogen. Then, the PTH/PTHrP receptor mRNA was located in the inner root sheath (IRS) in anagen and catagen, but was not detected in telogen hair follicles, although it was expressed weakly in dermis. The variety of the PTH/PTHrP receptor mRNA expression during hair cycling suggest that PTH, PTHrP and their receptors might participate in the regulation of hair cycle in mice skin. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000179737500007
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50664
Collection北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, First Hosp, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Sch Med, Dept Pathol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, Y,Yang, SX,Tu, P,et al. Expression of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in mice hair cycle[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2002,30(2):136-141.
APA Wang, Y,Yang, SX,Tu, P,Zhang, B,&Ma, SQ.(2002).Expression of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in mice hair cycle.JOURNAL OF DERMATOLOGICAL SCIENCE,30(2),136-141.
MLA Wang, Y,et al."Expression of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in mice hair cycle".JOURNAL OF DERMATOLOGICAL SCIENCE 30.2(2002):136-141.
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