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学科主题: 临床医学
题名:
Expression of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in mice hair cycle
作者: Wang, Y1; Yang, SX1; Tu, P1; Zhang, B1; Ma, SQ1
关键词: parathyroid hormone/parathyroid hormone-related peptide receptor ; mice ; hair cycle
刊名: JOURNAL OF DERMATOLOGICAL SCIENCE
发表日期: 2002-11-01
卷: 30, 期:2, 页:136-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: PROTEIN-KINASE-C ; IMMUNOHISTOCHEMICAL LOCALIZATION ; HUMORAL HYPERCALCEMIA ; HUMAN KERATINOCYTES ; ADENYLATE-CYCLASE ; FIBER PRODUCTION ; FOLLICLE GROWTH ; ORGAN-CULTURE ; SKIN ; IDENTIFICATION
英文摘要:

There is increasing evidence that parathyroid hormone (PTH) and PTH-related peptide (PTHrP) are involved in normal skin cell growth, influence the proliferation and differentiation of the epidermis and hair follicle. PTHrP and PTH/PTHrP receptor show prominent cutaneous expression, may exert important paracrine and/or autocrine functions. The expression of PTH/PTHrP receptor in different stages of hair cycle is unknown. Therefore, we examined the amount of PTH/PTHrP mRNA in C57BL/6 mice skin at different stages of hair cycle by relatively quantitative reverse transcription-polymerase chain reaction (RT-PCR), and investigated the localization of this receptor in mice skin by in situ hybridization. The expression of PTH/PTHrP receptor mRNA were higher in anagen, but significantly lower in catagen and telogen. Then, the PTH/PTHrP receptor mRNA was located in the inner root sheath (IRS) in anagen and catagen, but was not detected in telogen hair follicles, although it was expressed weakly in dermis. The variety of the PTH/PTHrP receptor mRNA expression during hair cycling suggest that PTH, PTHrP and their receptors might participate in the regulation of hair cycle in mice skin. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000179737500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50664
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Dept Dermatol, Beijing 100034, Peoples R China
2.Peking Univ, Sch Med, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Y,Yang, SX,Tu, P,et al. Expression of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in mice hair cycle[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2002,30(2):136-141.
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