学科主题基础医学
Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats
Zeng, Qiang1; Yuan, Ying1; Wang, Xi1; Wu, Hong Mei1; Fan, Li1; Qi, Yong Fen2; Tang, Chao Shu2; Cai, Yan2; Pan, Chun Shui2
关键词Spontaneously hypertensive rats Intermedin/adrenomedullin 2 Calcitonin receptor-like receptor Receptor activity-modifying proteins cAMP
刊名PEPTIDES
2009-02-01
DOI10.1016/j.peptides.2008.10.021
30期:2页:391-399
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ACTIVITY-MODIFYING PROTEINS ; GENE-RELATED PEPTIDE ; ADRENOMEDULLIN RECEPTORS ; ISCHEMIA/REPERFUSION INJURY ; HEART-FAILURE ; INTERMEDIN/ADRENOMEDULLIN-2 ; CALCITONIN ; CELLS ; PROADRENOMEDULLIN ; SECRETION
英文摘要

Intermedin (IMD), also called adrenomedullin 2 (ADM2), is a 47-amino acid peptide belonging to the calcitonin/calcitonin gene-related peptide (CGRP) family. IMD has similar or more potent vasodilatory and hypotensive actions compared with adrenomedullin (ADM) and CGRP. This study was designed to explore the role of IMD and its receptor in the pathogenesis of spontaneous hypertension and cardiac hypertrophy. Radioimmunoassay was employed to determine plasma immunoreactive IMD concentration and tissue immunoreactive IMD levels in the myocardium and aorta as well as cAMP concentration in the cardiovascular tissues in 13-week-old Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). The mRNA expression of IMD, its receptor, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP)) were determined by semi-quantitative RT-PCR. Protein levels of CRLR and RAMPs were assayed by Western blotting. Our results showed that immunoreactive IMID concentration was enhanced in the SHR myocardium, aortas and plasma. Both the mRNA and protein levels of IMD, as well as those of CRLR and RAMP 1-3 were upregulated in SHRs. IMD affected cAMP generation in the myocardium and aorta, which were not attenuated by prior addition of either CGRP8-37 or ADM22-52 alone. These results indicate that the elevation of IMD and its receptor in the cardiovascular tissue may play an important role in the pathogenesis of spontaneous hypertension. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000263447700025
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50666
专题北京大学基础医学院_生理学与病理生理学系
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol 2, Beijing 100853, Peoples R China
2.Peking Univ, Dept Physiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zeng, Qiang,Yuan, Ying,Wang, Xi,et al. Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats[J]. PEPTIDES,2009,30(2):391-399.
APA Zeng, Qiang.,Yuan, Ying.,Wang, Xi.,Wu, Hong Mei.,Fan, Li.,...&Pan, Chun Shui.(2009).Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats.PEPTIDES,30(2),391-399.
MLA Zeng, Qiang,et al."Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats".PEPTIDES 30.2(2009):391-399.
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