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学科主题: 基础医学
题名:
Parallel pain processing in freely moving rats revealed by distributed neuron recording
作者: Wang, JY1; Luo, F1; Chang, JY1; Woodward, DJ1; Han, JS1
关键词: primary somatosensory cortex ; cingulate cortex ; thalamus ; nociception ; microelectrode
刊名: BRAIN RESEARCH
发表日期: 2003-12-05
DOI: 10.1016/j.brainres.2003.08.059
卷: 992, 期:2, 页:263-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PRIMARY SOMATOSENSORY CORTEX ; NOXIOUS THERMAL-STIMULATION ; CORTICAL REPRESENTATION ; NOCICEPTIVE NEURONS ; CINGULATE CORTEX ; BRAIN RESPONSES ; CEREBRAL-CORTEX ; BASAL GANGLIA ; PERCEPTION ; MECHANISMS
英文摘要:

The present study was designed to examine the possible differential roles of the medial and lateral pain systems in pain perception. We used a microwire array recording technique to record the pain-evoked neural activity of multiple neurons in freely moving rats. Noxious radiant heat was delivered to either hind-paw in a randomized order. A total of 256 single units were recorded in primary somatosensory cortex (SI), anterior cingulate cortex (ACC), and medial dorsal (MD) and ventral posterior (VP) thalamus during the painful stimulation. The results showed that SI neurons displayed a strong pain-related excitatory response with short duration and significant contralateral bias; VP had very similar functional patterns to that of SI. This suggested that SI, together with VP, participate in the processing of the sensory-discriminative aspect of pain. In contrast, ACC and MD shared common characteristics of moderate and longer-lasting increase of neural activity, bilateral receptive fields without contralateral preference, as well as the anticipatory response at the start of a painful stimulus, corresponding to the specific role of ACC and MD in the affective-motivational aspects of pain. The results provide an initial demonstration of distributed activity patterns within different pain systems in awake and freely moving rats, hence, providing confirmation of the existence of the dual pain pathways. (C) 2003 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000186887900012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50669
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
3.Wake Forest Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA

Recommended Citation:
Wang, JY,Luo, F,Chang, JY,et al. Parallel pain processing in freely moving rats revealed by distributed neuron recording[J]. BRAIN RESEARCH,2003,992(2):263-271.
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