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IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat
作者: Zhang, Yonggang1; Li, Yuguang1; Wei, Ruihong2; Wang, Zhijian3; Bu, Dingfang3; Zhao, Jing3; Pang, Yongzheng3; Tang, Chaoshu3
关键词: Adventitial fibroblasts ; Peptide ; GPR(14) ; Receptor ; Collagen ; Vascular remodeling ; Proliferation
刊名: REGULATORY PEPTIDES
发表日期: 2008-11-29
DOI: 10.1016/j.regpep.2008.10.004
卷: 151, 期:1-3, 页:88-94
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Physiology
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; FUNCTIONAL RECEPTORS ; INCREASED EXPRESSION ; NADPH OXIDASE ; FIBROBLASTS ; ATHEROSCLEROSIS ; HYPERTENSION ; IMMUNOREACTIVITY ; PROLIFERATION ; INFLAMMATION
英文摘要:

Urotensin II(UII) is a potent vasoconstrictive peptide: however, its significance in vascular adventitia has not been clearly elucidated. In this study, rat aortic adventitia showed mRNA expression and immunoreactivity of UII and its receptor (UT). Moreover, radioligand-binding assay showed that maximum binding capacity (Borax) of [(125)l]-UII was higher in adventitia than in media (28.60 +/- 1.94 vs. 20.21 +/- 1.11 fmol/mg. P<0.01). with no difference in binding affinity (dissociation constant [Kd] 4.27 +/- 0.49 vs. 4.60 +/- 0.40 nM, P>0.05). Furthermore, in cultured adventitial fibroblasts. UII stimulated DNA synthesis, collagen synthesis and secretion in a concentration-dependent manner. These effects were inhibited by the UII receptor antagonist urantide (10(-6) mol/l), Ca(2+) channel blocker nicardipine (10(-5) mol/l), protein kinase C inhibitor H7 (10(-6) mol/l), and mitogen-activated protein kinase inhibitor PD98059 (10(-6) mol/l) but not the phosphatidyl inositol-3 kinase inhibitor wortmannin (10(-7) mol/l). UII may act as an autocrine/paracrine factor through its receptor and the Ca(2+) channel. protein kinase C, and mitogen-activated protein kinase signal transduction pathways, in the pathogenesis of vascular remodeling by activating vascular adventitia. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30470730 ; 2003033439 ; A2007425 ; G2000056905
项目资助者: National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Medical Science Foundation of Guangdong Province Health Department ; Major State Basic Research Development Program of China
WOS记录号: WOS:000261813500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50675
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Cardiovasc Dis, Shantou 515041, Guangdong, Peoples R China
2.Shantou Univ, Coll Med, Affiliated Hosp 2, Shantou 515041, Peoples R China
3.Peking Univ First Hosp, Inst Cardiovasc Res, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Yonggang,Li, Yuguang,Wei, Ruihong,et al. Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat[J]. REGULATORY PEPTIDES,2008,151(1-3):88-94.
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