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学科主题临床医学
Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat
Zhang, Yonggang1; Li, Yuguang1; Wei, Ruihong2; Wang, Zhijian3; Bu, Dingfang3; Zhao, Jing3; Pang, Yongzheng3; Tang, Chaoshu3
关键词Adventitial Fibroblasts Peptide Gpr(14) Receptor Collagen Vascular Remodeling Proliferation
刊名REGULATORY PEPTIDES
2008-11-29
DOI10.1016/j.regpep.2008.10.004
151期:1-3页:88-94
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Physiology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; FUNCTIONAL RECEPTORS ; INCREASED EXPRESSION ; NADPH OXIDASE ; FIBROBLASTS ; ATHEROSCLEROSIS ; HYPERTENSION ; IMMUNOREACTIVITY ; PROLIFERATION ; INFLAMMATION
英文摘要

Urotensin II(UII) is a potent vasoconstrictive peptide: however, its significance in vascular adventitia has not been clearly elucidated. In this study, rat aortic adventitia showed mRNA expression and immunoreactivity of UII and its receptor (UT). Moreover, radioligand-binding assay showed that maximum binding capacity (Borax) of [(125)l]-UII was higher in adventitia than in media (28.60 +/- 1.94 vs. 20.21 +/- 1.11 fmol/mg. P<0.01). with no difference in binding affinity (dissociation constant [Kd] 4.27 +/- 0.49 vs. 4.60 +/- 0.40 nM, P>0.05). Furthermore, in cultured adventitial fibroblasts. UII stimulated DNA synthesis, collagen synthesis and secretion in a concentration-dependent manner. These effects were inhibited by the UII receptor antagonist urantide (10(-6) mol/l), Ca(2+) channel blocker nicardipine (10(-5) mol/l), protein kinase C inhibitor H7 (10(-6) mol/l), and mitogen-activated protein kinase inhibitor PD98059 (10(-6) mol/l) but not the phosphatidyl inositol-3 kinase inhibitor wortmannin (10(-7) mol/l). UII may act as an autocrine/paracrine factor through its receptor and the Ca(2+) channel. protein kinase C, and mitogen-activated protein kinase signal transduction pathways, in the pathogenesis of vascular remodeling by activating vascular adventitia. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000261813500014
项目编号30470730 ; 2003033439 ; A2007425 ; G2000056905
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Medical Science Foundation of Guangdong Province Health Department ; Major State Basic Research Development Program of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50675
专题北京大学第一临床医学院_心血管内科
作者单位1.Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Cardiovasc Dis, Shantou 515041, Guangdong, Peoples R China
2.Shantou Univ, Coll Med, Affiliated Hosp 2, Shantou 515041, Peoples R China
3.Peking Univ First Hosp, Inst Cardiovasc Res, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yonggang,Li, Yuguang,Wei, Ruihong,et al. Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat[J]. REGULATORY PEPTIDES,2008,151(1-3):88-94.
APA Zhang, Yonggang.,Li, Yuguang.,Wei, Ruihong.,Wang, Zhijian.,Bu, Dingfang.,...&Tang, Chaoshu.(2008).Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat.REGULATORY PEPTIDES,151(1-3),88-94.
MLA Zhang, Yonggang,et al."Urotensin II is an autocrine/paracrine growth factor for aortic adventitia of rat".REGULATORY PEPTIDES 151.1-3(2008):88-94.
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