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学科主题: 临床医学
题名:
Effect of modified Wuzi Yanzong Granule on patients with mild cognitive impairment from oxidative damage aspect
作者: Wang Xue-mei; Fu Hong; Liu Geng-xin; Zhu Wei; Yang Jin-xia
关键词: modified Wuzi Yanzong Granule ; mild cognitive impairment ; memory function ; oxidative damage ; beta-amyloid protein
刊名: CHINESE JOURNAL OF INTEGRATIVE MEDICINE
发表日期: 2007-12-01
DOI: 10.1007/s11655-007-0258-7
卷: 13, 期:4, 页:258-263
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: DISEASE
英文摘要:

Objective: To observe the effects of modified Wuzi Yanzong Granule (WYG) on memory function and the activity of serum superoxide dismutase (SOD), malondialdehyde (MDA) levels, leukocyte mitochondrial DNA (mtDNA) deletion rate and beta-amyloid protein(1-28) (A beta(1-28)) in patients with mild cognitive impairment (MCI). Methods: Thirty-six patients with MCI were selected based on the internationally recognized Petersen′s criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A beta(1-28), content were observed before and after treatment. Results: Compared with the normal control group, the memory quotient and SOD activity in patients with MCI decreased significantly (P < 0.01), while MDA, A beta(1-28) levels and the leukocyte mtDNA deletion rate increased significantly (P < 0.01). After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A beta(1-28) level decreased in the treated group compared with those before treatment (P<0.01, P<0.05). Meanwhile, leukocyte mtDNA deletion rate and A beta(1-28) content in the treated group were all lower than those in the control group (P<0.05). Conclusion: WYG could improve memory function in patients with MCI and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase, the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCI.

语种: 英语
WOS记录号: WOS:000254391200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50677
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, First Hosp, Dept Integrated Chinese & Western Med, Beijing 100034, Peoples R China

Recommended Citation:
Wang Xue-mei,Fu Hong,Liu Geng-xin,et al. Effect of modified Wuzi Yanzong Granule on patients with mild cognitive impairment from oxidative damage aspect[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2007,13(4):258-263.
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