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Effect of modified Wuzi Yanzong Granule on patients with mild cognitive impairment from oxidative damage aspect
Wang Xue-mei; Fu Hong; Liu Geng-xin; Zhu Wei; Yang Jin-xia
关键词Modified Wuzi Yanzong Granule Mild Cognitive Impairment Memory Function Oxidative Damage Beta-amyloid Protein
刊名CHINESE JOURNAL OF INTEGRATIVE MEDICINE
2007-12-01
DOI10.1007/s11655-007-0258-7
13期:4页:258-263
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]DISEASE
英文摘要

Objective: To observe the effects of modified Wuzi Yanzong Granule (WYG) on memory function and the activity of serum superoxide dismutase (SOD), malondialdehyde (MDA) levels, leukocyte mitochondrial DNA (mtDNA) deletion rate and beta-amyloid protein(1-28) (A beta(1-28)) in patients with mild cognitive impairment (MCI). Methods: Thirty-six patients with MCI were selected based on the internationally recognized Petersen′s criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A beta(1-28), content were observed before and after treatment. Results: Compared with the normal control group, the memory quotient and SOD activity in patients with MCI decreased significantly (P < 0.01), while MDA, A beta(1-28) levels and the leukocyte mtDNA deletion rate increased significantly (P < 0.01). After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A beta(1-28) level decreased in the treated group compared with those before treatment (P<0.01, P<0.05). Meanwhile, leukocyte mtDNA deletion rate and A beta(1-28) content in the treated group were all lower than those in the control group (P<0.05). Conclusion: WYG could improve memory function in patients with MCI and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase, the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCI.

语种英语
WOS记录号WOS:000254391200006
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50677
专题北京大学第一临床医学院
作者单位Peking Univ, First Hosp, Dept Integrated Chinese & Western Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang Xue-mei,Fu Hong,Liu Geng-xin,et al. Effect of modified Wuzi Yanzong Granule on patients with mild cognitive impairment from oxidative damage aspect[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2007,13(4):258-263.
APA Wang Xue-mei,Fu Hong,Liu Geng-xin,Zhu Wei,&Yang Jin-xia.(2007).Effect of modified Wuzi Yanzong Granule on patients with mild cognitive impairment from oxidative damage aspect.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,13(4),258-263.
MLA Wang Xue-mei,et al."Effect of modified Wuzi Yanzong Granule on patients with mild cognitive impairment from oxidative damage aspect".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 13.4(2007):258-263.
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