IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis
Meng, JH1; Ma, XC1; Ma, DL1; Xu, CM1
关键词Osteoarthritis Temporomandibular Joint Cartilage Differentially Expressed Gene Microarray
刊名OSTEOARTHRITIS AND CARTILAGE
2005-12-01
DOI10.1016/j.joca.2005.03.010
13期:12页:1115-1125
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Rheumatology
研究领域[WOS]Orthopedics ; Rheumatology
关键词[WOS]AQUAPORIN WATER CHANNELS ; ANTI-ANGIOGENIC FACTOR ; ARTICULAR CHONDROCYTES ; CHONDROMODULIN-I ; BONE ; BIOCHEMISTRY ; METABOLISM ; ONTOLOGY ; FAMILY ; GROWTH
英文摘要

Objective: To identify the gene expression profile of mandibular condylar cartilage after experimentally induced osteoarthritis (OA)

Design: We studied the gene expression levels in temporomandibular joint (TMJ) condylar cartilage during different stages of experimentally induced OA. The pathological characteristics of normal, early-stage and late-stage osteoarthritic TMJ cartilage were verified by histological techniques. The gene expression profiles in normal and osteoarthritic cartilage were measured by Affymetrix RAE230A microarrays. Some of the gene transcripts were confirmed by quantitative real-time reverse-transcription PCR analysis.

Results: A comprehensive, differentially expressed, gene profile was obtained in TMJ cartilage during the progression of OA. In total, 138 genes and expressed sequence tags were up- or down-regulated at least 2-fold. Some of these genes have been shown to play a role in OA, including matrix-degrading proteases, protease inhibitors and genes involved in cell growth, apoptosis and bone remodeling. However, some genes that had never been reported to be related with OA, such as AQP3, SPP2, NOV, DKK3 and EGLN3, were consistently observed to be up-regulated in this study, suggesting they may be involved in OA progression.

Conclusion: This study provides a new gene expression profile of the progression of OA. Further study of these OA-related genes may provide new insights into understanding the molecular mechanisms underlying OA. (c) 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000234014500009
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50679
专题北京大学口腔医学院
作者单位1.Peking Univ, Sch Stomatol, Ctr TMD & Orofacial Pain, Beijing 100081, Peoples R China
2.Peking Univ, Ctr Human Dis Gene Res, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
4.Peking Union Med Coll, Beijing 100005, Peoples R China
推荐引用方式
GB/T 7714
Meng, JH,Ma, XC,Ma, DL,et al. Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis[J]. OSTEOARTHRITIS AND CARTILAGE,2005,13(12):1115-1125.
APA Meng, JH,Ma, XC,Ma, DL,&Xu, CM.(2005).Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis.OSTEOARTHRITIS AND CARTILAGE,13(12),1115-1125.
MLA Meng, JH,et al."Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis".OSTEOARTHRITIS AND CARTILAGE 13.12(2005):1115-1125.
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