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学科主题临床医学
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity
Xu, Peng1; Liu, Lu1; Chen, Xiao-zhuo1; Li, Yun2; Liu, Jian2; Jin, Zhi-ping3; Wang, Guang-qiang3; Lei, Ping-sheng1
关键词Ketolide Acylide Antibacterial Activity Structure Modification
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2009-08-01
DOI10.1016/j.bmcl.2009.06.023
19期:15页:4079-4083
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]HIGHLY POTENT ; KETOLIDES ; PATHOGENS ; RESISTANT ; ANTIBIOTICS ; ACYLIDES
英文摘要

In an effort to find new antibiotics, a novel series of 14-membered macrolides with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains has been synthesized based on commercially available clarithromycin. Chemical transformation of hydroxy group at position C-3 afforded range of ketolides and acylides. Compared to telithromycin, compound 15a demonstrated improved in vitro activity against erythromycin-susceptible and -resistant strains. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000267900900017
项目编号30572275 ; 7062047
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50688
专题北京大学第一临床医学院_临床药理研究所
作者单位1.Jingxin Pharmaceut Co, Xinchang 312400, Zhejiang, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China
3.Peking Univ, Inst Clin Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Peng,Liu, Lu,Chen, Xiao-zhuo,et al. Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(15):4079-4083.
APA Xu, Peng.,Liu, Lu.,Chen, Xiao-zhuo.,Li, Yun.,Liu, Jian.,...&Lei, Ping-sheng.(2009).Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(15),4079-4083.
MLA Xu, Peng,et al."Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.15(2009):4079-4083.
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