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Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells
Wang, Nan1; Wang, Li-Wen2; Gou, Bao-Di1; Zhang, Tian-Lan2
关键词Hl-60 Leukaemia Nanoparticle Proliferation Realgar
刊名JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
2009
DOI10.1080/01932690802501691
30期:2页:237-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]ARSENIC TRIOXIDE
英文摘要

Realgar (As4S4) has recently been proved effective in the treatment of leukaemia in clinical trials. However, the poor solubility of realgar makes it difficult to conduct mechanistic study in cellular level. In this work, we prepared realgar nanoparticle (RNP) suspension and examined its effect on the proliferation of human myelocytic leukaemia HL-60 cells. The average diameter of the particles was 143nm and was stable against coalescence over a 15-month storage. The suspension inhibited cell proliferation dose-dependently at concentrations from 10 to 60M (As), a fact shedding light on the mechanism of realgar′s clinical effectiveness against hematopoietic malignancies.

语种英语
WOS记录号WOS:000262859400016
项目编号20271005 ; 20571006 ; 2062007
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Municipal Education Commission ; Beijing Talent Project
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50697
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Nan,Wang, Li-Wen,Gou, Bao-Di,et al. Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells[J]. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,2009,30(2):237-240.
APA Wang, Nan,Wang, Li-Wen,Gou, Bao-Di,&Zhang, Tian-Lan.(2009).Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells.JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,30(2),237-240.
MLA Wang, Nan,et al."Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells".JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY 30.2(2009):237-240.
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