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学科主题: 药学
题名:
Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells
作者: Wang, Nan1; Wang, Li-Wen2; Gou, Bao-Di1; Zhang, Tian-Lan2
关键词: HL-60 ; leukaemia ; nanoparticle ; proliferation ; realgar
刊名: JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
发表日期: 2009
DOI: 10.1080/01932690802501691
卷: 30, 期:2, 页:237-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: ARSENIC TRIOXIDE
英文摘要:

Realgar (As4S4) has recently been proved effective in the treatment of leukaemia in clinical trials. However, the poor solubility of realgar makes it difficult to conduct mechanistic study in cellular level. In this work, we prepared realgar nanoparticle (RNP) suspension and examined its effect on the proliferation of human myelocytic leukaemia HL-60 cells. The average diameter of the particles was 143nm and was stable against coalescence over a 15-month storage. The suspension inhibited cell proliferation dose-dependently at concentrations from 10 to 60M (As), a fact shedding light on the mechanism of realgar′s clinical effectiveness against hematopoietic malignancies.

语种: 英语
所属项目编号: 20271005 ; 20571006 ; 2062007
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Municipal Education Commission ; Beijing Talent Project
WOS记录号: WOS:000262859400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50697
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing, Peoples R China

Recommended Citation:
Wang, Nan,Wang, Li-Wen,Gou, Bao-Di,et al. Preparation of Realgar Nanoparticle Suspension and Its Inhibition Effect on the Proliferation of Human Myelocytic Leukaemia HL-60 Cells[J]. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,2009,30(2):237-240.
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