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All-trans Retinoic Acid Promotes Cell Apoptosis Through Gamma Amino Butyric Acid Pathway in Murine Embryonic Palate Mesenchymal Cells
Wei Xue-Tao1,2; Qiao Yang-Zheng2; Shang Lan-Qin2; Li Yong1
关键词All-trans Retinoic Acid Murine Embryonic Palate Mesenchymal Cell Glutamic Acid Decarboxylase Gamma Amino Butyric Acid Proliferation Apoptosis
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
2012-03-01
DOI10.3724/SP.J.1206.2011.00199
39期:3页:264-272
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CLEFT-PALATE ; GABA(A) RECEPTORS ; DEFICIENT MICE ; EXPRESSION ; DECARBOXYLASE ; SUBUNIT ; SHELF ; GENE ; MODULATION ; INDUCTION
英文摘要

Retinoic acid (RA) is a teratogen which can induce cleft palate. Recent studies suggested that gamma amino butyric acid (GABA) was involved in the development of palate. If the GABA signal pathway participates the cleft palate induced by RA remains to be elucidated. In the present study, we investigated the effect of all-trans retinoic acid (atRA) (0.2, 0.67, 2.0 and 6.7 mu mol/L) on cell proliferation and apoptosis, and then examined the role of gamma amino butyric acid (GABA) signaling pathway in regulation of cell proliferation and apoptosis by atRA in murine embryonic palate mesenchymal (MEPM) cells. Results showed that atRA (2 mu mol/L and 6.7 mu mol/L) significantly inhibited cell proliferation and increased apoptosis. The mRNA and protein expression of glutamic acid decarboxylase 67 (GAD 67) which was a key enzyme in synthesis of GABA were significantly down regulated by atRA (0.67, 2.0 mu mol/L and 6.7 mu mol/L). But the mRNA and protein expression of GABAAR-133 were shown no obvious change compared with the control group. When GABA (1.0 mu mol/L) was added to cell culture system, the effect of atRA (6.7 mu mol/L) on the proliferation and apoptosis of MEPM cells was reversed. In conclusion, all-trans retinoic acid inhibits cell proliferation and promotes cell apoptosis through gamma amino butyric acid pathway in murine embryonic palate mesenchymal cells.

语种英语
WOS记录号WOS:000301895500010
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50698
专题北京大学公共卫生学院
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Toxicol, Hlth Sci Ctr, Beijing 100083, Peoples R China
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Wei Xue-Tao,Qiao Yang-Zheng,Shang Lan-Qin,et al. All-trans Retinoic Acid Promotes Cell Apoptosis Through Gamma Amino Butyric Acid Pathway in Murine Embryonic Palate Mesenchymal Cells[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(3):264-272.
APA Wei Xue-Tao,Qiao Yang-Zheng,Shang Lan-Qin,&Li Yong.(2012).All-trans Retinoic Acid Promotes Cell Apoptosis Through Gamma Amino Butyric Acid Pathway in Murine Embryonic Palate Mesenchymal Cells.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(3),264-272.
MLA Wei Xue-Tao,et al."All-trans Retinoic Acid Promotes Cell Apoptosis Through Gamma Amino Butyric Acid Pathway in Murine Embryonic Palate Mesenchymal Cells".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.3(2012):264-272.
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