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学科主题: 临床医学
题名:
Characterization of beta-defensin 42 expressed in principal cells at the initial segment of the rat epididymis
作者: Xin, Aijie1; Zhao, Yue2; Yu, Heguo3; Shi, Huijuan3; Diao, Hua3; Zhang, Yonglian1,3,4
关键词: beta-defensin 42 ; epididymis ; initial segment ; sperm ; antimicrobial activity
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2015-11-01
DOI: 10.1093/abbs/gmv089
卷: 47, 期:11, 页:861-869
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: MALE REPRODUCTIVE-TRACT ; GENE-EXPRESSION ; POSTNATAL-DEVELOPMENT ; SPERM MATURATION ; MOUSE EPIDIDYMIS ; IDENTIFICATION ; FAMILY ; TRANSCRIPTOMES ; LOCALIZATION ; SPERMATOZOA
英文摘要:

beta-defensins, preferentially expressed in male reproductive tracts, particularly in the testes and epididymis with region-specific patterns, play an important role in both innate immunity and sperm fertility. Expressed in the caput region of epididymis, beta-defensins have been known to contribute to innate immunity, sperm motility initiation, and maintenance. However, beta-defensins of the initial region remain to be uncharacterized. In this study, rat beta-defensin 42 (Defb42) was revealed to be exclusively located in the principal cells at the initial segment of the rat epididymis and its sperm′s acrosome. Furthermore, the expression of Defb42 was dependent on luminal testicular factors and developmental phases. The recombinant Defb42 was predominantly antimicrobial not against Candida albicans, but against Escherichia coli and Staphylococcus aureus. Based on these findings, Defb42 was suggested to play a dual role in sperm fertility and host defense in rat epididymis.

语种: 英语
所属项目编号: 81401252 ; 81270744 ; 2009CB941700
项目资助者: National Natural Science Foundation of China ; State Key Development Program for Basic Research of China
WOS记录号: WOS:000363845000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50704
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China
3.Fudan Univ, SIPPR, China Natl Populat & Family Planning Key Lab Cont, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, Shanghai 200031, Peoples R China

Recommended Citation:
Xin, Aijie,Zhao, Yue,Yu, Heguo,et al. Characterization of beta-defensin 42 expressed in principal cells at the initial segment of the rat epididymis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015,47(11):861-869.
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