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Characterization of beta-defensin 42 expressed in principal cells at the initial segment of the rat epididymis
Xin, Aijie1; Zhao, Yue2; Yu, Heguo3; Shi, Huijuan3; Diao, Hua3; Zhang, Yonglian1,3,4
关键词Beta-defensin 42 Epididymis Initial Segment Sperm Antimicrobial Activity
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2015-11-01
DOI10.1093/abbs/gmv089
47期:11页:861-869
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]MALE REPRODUCTIVE-TRACT ; GENE-EXPRESSION ; POSTNATAL-DEVELOPMENT ; SPERM MATURATION ; MOUSE EPIDIDYMIS ; IDENTIFICATION ; FAMILY ; TRANSCRIPTOMES ; LOCALIZATION ; SPERMATOZOA
英文摘要

beta-defensins, preferentially expressed in male reproductive tracts, particularly in the testes and epididymis with region-specific patterns, play an important role in both innate immunity and sperm fertility. Expressed in the caput region of epididymis, beta-defensins have been known to contribute to innate immunity, sperm motility initiation, and maintenance. However, beta-defensins of the initial region remain to be uncharacterized. In this study, rat beta-defensin 42 (Defb42) was revealed to be exclusively located in the principal cells at the initial segment of the rat epididymis and its sperm′s acrosome. Furthermore, the expression of Defb42 was dependent on luminal testicular factors and developmental phases. The recombinant Defb42 was predominantly antimicrobial not against Candida albicans, but against Escherichia coli and Staphylococcus aureus. Based on these findings, Defb42 was suggested to play a dual role in sperm fertility and host defense in rat epididymis.

语种英语
WOS记录号WOS:000363845000001
项目编号81401252 ; 81270744 ; 2009CB941700
资助机构National Natural Science Foundation of China ; State Key Development Program for Basic Research of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50704
专题北京大学第三临床医学院_生殖医学中心
作者单位1.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China
3.Fudan Univ, SIPPR, China Natl Populat & Family Planning Key Lab Cont, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, Shanghai 200031, Peoples R China
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GB/T 7714
Xin, Aijie,Zhao, Yue,Yu, Heguo,et al. Characterization of beta-defensin 42 expressed in principal cells at the initial segment of the rat epididymis[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015,47(11):861-869.
APA Xin, Aijie,Zhao, Yue,Yu, Heguo,Shi, Huijuan,Diao, Hua,&Zhang, Yonglian.(2015).Characterization of beta-defensin 42 expressed in principal cells at the initial segment of the rat epididymis.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,47(11),861-869.
MLA Xin, Aijie,et al."Characterization of beta-defensin 42 expressed in principal cells at the initial segment of the rat epididymis".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47.11(2015):861-869.
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