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IR@PKUHSC  > 北京大学第二临床医学院  > 肾内科  > 期刊论文
学科主题: 临床医学
题名:
Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients
作者: Wei, Tao; Wang, Mei; Wang, Mi; Gan, Liang-Ying; Li, Xin
关键词: Hemodialysis ; Cardiovascular events ; Soluble receptor activator of nuclear factor-kappa B ligand ; Vascular calcification
刊名: BLOOD PURIFICATION
发表日期: 2009
DOI: 10.1159/000232941
卷: 28, 期:4, 页:342-345
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Urology & Nephrology
研究领域[WOS]: Hematology ; Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; SOLUBLE RANK LIGAND ; LOW SERUM-LEVELS ; OSTEOPROTEGERIN ; RISK
英文摘要:

Background: Vascular calcification and cardiovascular events are common in hemodialysis patients. Receptor activator of nuclear factor-kappa B ligand (RANKL) plays an important role in vascular calcification and bone remodeling. This study investigates the effects of soluble RANKL (sRANKL) on cardiovascular events in hemodialysis patients. Methods: Serum sRANKL levels of 47 patients were tested by ELISA. Vascular calcification was radiographically measured and patients were followed up for 2 years. Results: After 2 years, 10 (36.6%) patients had experienced cardiovascular events. Seventy-five percent (6/9) of mortality was due to cardiovascular disease. Patients experiencing cardiovascular events showed significantly higher vascular calcification scores (VCS) (3.20 +/- 2.74 vs. 1.19 +/- 1.60; t = 2.999; p < 0.05). Multivariate regression analysis showed that serum sRANKL levels, vascular calcification scores and phosphorus were independent determinants of cardiovascular events. Conclusion: Serum sRANKL levels and VCS are independent risk factors, and hemodialysis patients with low serum sRANKL levels have a risk of cardiovascular events. Copyright (C) 2009 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000272338500087
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50719
Appears in Collections:北京大学第二临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China

Recommended Citation:
Wei, Tao,Wang, Mei,Wang, Mi,et al. Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients[J]. BLOOD PURIFICATION,2009,28(4):342-345.
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