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Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients
Wei, Tao; Wang, Mei; Wang, Mi; Gan, Liang-Ying; Li, Xin
关键词Hemodialysis Cardiovascular Events Soluble Receptor Activator Of Nuclear Factor-kappa b Ligand Vascular Calcification
刊名BLOOD PURIFICATION
2009
DOI10.1159/000232941
28期:4页:342-345
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Urology & Nephrology
研究领域[WOS]Hematology ; Urology & Nephrology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; SOLUBLE RANK LIGAND ; LOW SERUM-LEVELS ; OSTEOPROTEGERIN ; RISK
英文摘要

Background: Vascular calcification and cardiovascular events are common in hemodialysis patients. Receptor activator of nuclear factor-kappa B ligand (RANKL) plays an important role in vascular calcification and bone remodeling. This study investigates the effects of soluble RANKL (sRANKL) on cardiovascular events in hemodialysis patients. Methods: Serum sRANKL levels of 47 patients were tested by ELISA. Vascular calcification was radiographically measured and patients were followed up for 2 years. Results: After 2 years, 10 (36.6%) patients had experienced cardiovascular events. Seventy-five percent (6/9) of mortality was due to cardiovascular disease. Patients experiencing cardiovascular events showed significantly higher vascular calcification scores (VCS) (3.20 +/- 2.74 vs. 1.19 +/- 1.60; t = 2.999; p < 0.05). Multivariate regression analysis showed that serum sRANKL levels, vascular calcification scores and phosphorus were independent determinants of cardiovascular events. Conclusion: Serum sRANKL levels and VCS are independent risk factors, and hemodialysis patients with low serum sRANKL levels have a risk of cardiovascular events. Copyright (C) 2009 S. Karger AG, Basel

语种英语
WOS记录号WOS:000272338500087
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50719
专题北京大学第二临床医学院_肾内科
北京大学医学部管理机构_医学部
作者单位Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wei, Tao,Wang, Mei,Wang, Mi,et al. Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients[J]. BLOOD PURIFICATION,2009,28(4):342-345.
APA Wei, Tao,Wang, Mei,Wang, Mi,Gan, Liang-Ying,&Li, Xin.(2009).Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients.BLOOD PURIFICATION,28(4),342-345.
MLA Wei, Tao,et al."Relationship of sRANKL Level and Vascular Calcification Score to Cardiovascular Events in Maintenance Hemodialysis Patients".BLOOD PURIFICATION 28.4(2009):342-345.
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