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Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta-analysis
Xie, Yan-Di; Feng, Bo; Gao, Yan; Wei, Lai
关键词Abstinence Meta-analysis Alcoholic Cirrhosis Continue Drinking Abstinent
刊名HEPATOLOGY RESEARCH
2014-04-01
DOI10.1111/hepr.12131
44期:4页:436-449
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]NATURAL-HISTORY ; LIVER-CIRRHOSIS ; HEPATITIS-C ; PROGNOSTIC INDICATORS ; DISEASE ; DRINKING ; OUTCOMES
英文摘要

Aim

To address the questions of whether abstinence improves survival of patients with alcoholic cirrhosis (AC) and how long it takes for the effect to be significant.

Methods

A systematic review and a meta-analysis are performed to assess the effect of abstinence on the survival of patients with AC.

Results

Seven cohort studies involving 1235 patients with AC were included. No differences were found in 0.5-year survival (hazard ratio [HR] = 0.48, 95% confidence interval [CI] = 0.23-1.03, P = 0.06) and 1-year survival (HR = 0.58, 95% CI = 0.32-1.03, P = 0.06) between the abstinent and continue drinking groups. However, differences were found in 1.5-year survival (HR = 0.51, 95% CI = 0.33-0.81, P = 0.004), 2-year survival (HR = 0.55, 95% CI = 0.38-0.78, P = 0.0008), 2.5-year survival (HR = 0.54, 95% CI = 0.38-0.77, P = 0.0005), 3-year survival (HR = 0.54, 95% CI = 0.40-0.74, P = 0.0001), 3.5-year survival (HR = 0.56, 95% CI = 0.44-0.73, P < 0.00001), 4-year survival (HR = 0.60, 95% CI = 0.48-0.73, P < 0.00001), 4.5-year survival (HR = 0.61, 95% CI = 0.49-0.76, P < 0.0001) and 5-year survival (HR = 0.63, 95% CI = 0.52-0.76, P < 0.00001) between the two groups.

Conclusion

Alcohol abstinence does improve the survival of patients with AC, and it takes at least 1.5 years of alcohol abstinence before a statistically significant difference in survival can be observed between the abstinent and the continue drinking groups.

语种英语
WOS记录号WOS:000333632700011
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50720
专题北京大学第二临床医学院_感染科
北京大学第二临床医学院_肝病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xie, Yan-Di,Feng, Bo,Gao, Yan,et al. Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta-analysis[J]. HEPATOLOGY RESEARCH,2014,44(4):436-449.
APA Xie, Yan-Di,Feng, Bo,Gao, Yan,&Wei, Lai.(2014).Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta-analysis.HEPATOLOGY RESEARCH,44(4),436-449.
MLA Xie, Yan-Di,et al."Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta-analysis".HEPATOLOGY RESEARCH 44.4(2014):436-449.
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