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学科主题: 临床医学
题名:
Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta-analysis
作者: Xie, Yan-Di; Feng, Bo; Gao, Yan; Wei, Lai
关键词: abstinence ; meta-analysis ; alcoholic cirrhosis ; continue drinking ; abstinent
刊名: HEPATOLOGY RESEARCH
发表日期: 2014-04-01
DOI: 10.1111/hepr.12131
卷: 44, 期:4, 页:436-449
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: NATURAL-HISTORY ; LIVER-CIRRHOSIS ; HEPATITIS-C ; PROGNOSTIC INDICATORS ; DISEASE ; DRINKING ; OUTCOMES
英文摘要:

Aim

To address the questions of whether abstinence improves survival of patients with alcoholic cirrhosis (AC) and how long it takes for the effect to be significant.

Methods

A systematic review and a meta-analysis are performed to assess the effect of abstinence on the survival of patients with AC.

Results

Seven cohort studies involving 1235 patients with AC were included. No differences were found in 0.5-year survival (hazard ratio [HR] = 0.48, 95% confidence interval [CI] = 0.23-1.03, P = 0.06) and 1-year survival (HR = 0.58, 95% CI = 0.32-1.03, P = 0.06) between the abstinent and continue drinking groups. However, differences were found in 1.5-year survival (HR = 0.51, 95% CI = 0.33-0.81, P = 0.004), 2-year survival (HR = 0.55, 95% CI = 0.38-0.78, P = 0.0008), 2.5-year survival (HR = 0.54, 95% CI = 0.38-0.77, P = 0.0005), 3-year survival (HR = 0.54, 95% CI = 0.40-0.74, P = 0.0001), 3.5-year survival (HR = 0.56, 95% CI = 0.44-0.73, P < 0.00001), 4-year survival (HR = 0.60, 95% CI = 0.48-0.73, P < 0.00001), 4.5-year survival (HR = 0.61, 95% CI = 0.49-0.76, P < 0.0001) and 5-year survival (HR = 0.63, 95% CI = 0.52-0.76, P < 0.00001) between the two groups.

Conclusion

Alcohol abstinence does improve the survival of patients with AC, and it takes at least 1.5 years of alcohol abstinence before a statistically significant difference in survival can be observed between the abstinent and the continue drinking groups.

语种: 英语
WOS记录号: WOS:000333632700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50720
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China

Recommended Citation:
Xie, Yan-Di,Feng, Bo,Gao, Yan,et al. Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta-analysis[J]. HEPATOLOGY RESEARCH,2014,44(4):436-449.
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