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学科主题: 药学
题名:
Granuloma maturation in the rat is advanced by the oral administration of Eucommia ulmoides OLIVER leaf
作者: Li, YM1; Metori, K1; Koike, K1; Kita, F1; Che, QM1; Sato, T1; Shirai, W1; Takahashi, S1
关键词: Eucommia ulmoides OLIVER ; leaf ; granuloma ; maturation ; collagen ; synthesis
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2000
卷: 23, 期:1, 页:60-65
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DU-ZHONG LEAF ; MUSCLE PROTEIN ; GRANULATION-TISSUE ; HEPATIC LIPIDS ; MEAT TEXTURE ; CULTURED EEL ; TOCHU LEAF ; CONSTITUENTS ; EXTRACT ; PROLIFERATION
英文摘要:

We have reported that collagen metabolism was improved by the administration of Eucommia ulmoides OLIVER leaf, In this paper, we examine the granuloma maturation and deposition of collagen in the granuloma of rats due to the oral administration of this leaf. After 3 weeks of the oral administration, granuloma formation was induced by the formalin soaked filter paper-pellet method. A week later, the developing granuloma was dissected. Granuloma formation was significantly increased due to ingestion of the dried leaf at a dose of 1.8 g/kg of body weight/d. The collagen content in the granuloma was also significantly increased. In the case of the collagen profile, the pepsin-solubilized collagen content and its relative percentage to the total collagen were significantly higher than in the control. Histochemical examination showed that the granuloma tissues were well developed, and displayed many newly synthesized capillary vessels and a greater quantity of fibroblasts and monocytes in the 1.8 g leaf group. High density lipoprotein (HDL)-cholesterol and triglyceride content in the blood plasma were significantly higher than in the control, These results show that granuloma maturation was accelerated and the energy was supplied from fatty acid metabolism. The administration of Eucommia ulmoides OLIVER leaf may be effective at speeding up the wound healing process.

语种: 英语
WOS记录号: WOS:000084907600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50722
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Nihon Univ, Coll Pharm, Biochem Lab, Chiba 2748555, Japan
2.Nihon Univ, Coll Ind Technol, Chiba 2758575, Japan
3.Nihon Univ, Coll Pharm, Ctr Analyt Chem, Chiba 2748555, Japan
4.SS Pharmaceut Co Ltd, Div Res & Dev, Chuo Ku, Tokyo, Japan
5.Nihon Univ, Coll Bioresource Sci, Fujisawa, Kanagawa 252, Japan
6.Beijing Med Univ, Sch Pharmaceut Sci, Dept Tradit Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
Li, YM,Metori, K,Koike, K,et al. Granuloma maturation in the rat is advanced by the oral administration of Eucommia ulmoides OLIVER leaf[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2000,23(1):60-65.
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