|Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants|
|Chen, Yi1,2; Feng, Jing1,2; Gilbert, Clare3; Yin, Hong1,2; Liang, Jianhong1,2; Li, Xiaoxin1,2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||THRESHOLD RETINOPATHY ; MULTICENTER TRIAL ; COUNTRIES ; CRYOTHERAPY ; OUTCOMES ; AGE|
To investigate the postmenstrual (PMA) age at treatment of severe retinopathy of prematurity (i.e. Type 1 prethreshold or threshold) in infants in a tertiary referral center in China.
76.6% (359/469) of infants were treated for threshold disease. 67.5% (317/469) of infants had a birth weight (BW) of 1250g or above and almost 30% (126) had a gestational age (GA) of 32 weeks or above. There was little difference in the characteristics of infants treated for Type 1 prethreshold or threshold ROP. After controlling for GA, PMA age at treatment was highest in infants with BW >= 2000g (mean PMA 40.3 +/- 4.4 weeks, p<0.001); after controlling for BW, higher GA was associated with higher PMA at treatment (mean PMA 41.5 weeks for gestational age >34 weeks, p<0.001). For every three weeks increase in GA there was a two-week increase in PMA at treatment (R2 = 0.20, p<0.001). The time at treatment of Type 1 prethreshold disease was similar to that for threshold disease i.e. chronological age 5.6-7.4 weeks, or PMA 34.1-40.2 weeks but the lower end of the 95% confidence interval for chronological age for Type 1 prethreshold disease among infants with BW >= 2000g was 3.7 weeks (i.e. before the recommended interval of 4-6 weeks after birth).
The Chinese guidelines regarding timing of the first examination are appropriate for infants with BW <2000g, but more mature infants should be examined a little earlier, at 3 weeks after birth, in order to detect Type 1 prethreshold disease which has a better prognosis than threshold.
|作者单位||1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
3.London Sch Hyg & Trop Med, Dept Clin Res, Int Ctr Eye Hlth, London WC1, England
|Chen, Yi,Feng, Jing,Gilbert, Clare,et al. Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants[J]. PLOS ONE,2015,10(2).|
|APA||Chen, Yi,Feng, Jing,Gilbert, Clare,Yin, Hong,Liang, Jianhong,&Li, Xiaoxin.(2015).Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants.PLOS ONE,10(2).|
|MLA||Chen, Yi,et al."Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants".PLOS ONE 10.2(2015).|