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Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants
Chen, Yi1,2; Feng, Jing1,2; Gilbert, Clare3; Yin, Hong1,2; Liang, Jianhong1,2; Li, Xiaoxin1,2
刊名PLOS ONE
2015-02-09
DOI10.1371/journal.pone.0116669
10期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]THRESHOLD RETINOPATHY ; MULTICENTER TRIAL ; COUNTRIES ; CRYOTHERAPY ; OUTCOMES ; AGE
英文摘要

Purpose

To investigate the postmenstrual (PMA) age at treatment of severe retinopathy of prematurity (i.e. Type 1 prethreshold or threshold) in infants in a tertiary referral center in China.

Principal Findings

76.6% (359/469) of infants were treated for threshold disease. 67.5% (317/469) of infants had a birth weight (BW) of 1250g or above and almost 30% (126) had a gestational age (GA) of 32 weeks or above. There was little difference in the characteristics of infants treated for Type 1 prethreshold or threshold ROP. After controlling for GA, PMA age at treatment was highest in infants with BW >= 2000g (mean PMA 40.3 +/- 4.4 weeks, p<0.001); after controlling for BW, higher GA was associated with higher PMA at treatment (mean PMA 41.5 weeks for gestational age >34 weeks, p<0.001). For every three weeks increase in GA there was a two-week increase in PMA at treatment (R2 = 0.20, p<0.001). The time at treatment of Type 1 prethreshold disease was similar to that for threshold disease i.e. chronological age 5.6-7.4 weeks, or PMA 34.1-40.2 weeks but the lower end of the 95% confidence interval for chronological age for Type 1 prethreshold disease among infants with BW >= 2000g was 3.7 weeks (i.e. before the recommended interval of 4-6 weeks after birth).

Significance

The Chinese guidelines regarding timing of the first examination are appropriate for infants with BW <2000g, but more mature infants should be examined a little earlier, at 3 weeks after birth, in order to detect Type 1 prethreshold disease which has a better prognosis than threshold.

语种英语
WOS记录号WOS:000349123100011
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50729
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
3.London Sch Hyg & Trop Med, Dept Clin Res, Int Ctr Eye Hlth, London WC1, England
推荐引用方式
GB/T 7714
Chen, Yi,Feng, Jing,Gilbert, Clare,et al. Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants[J]. PLOS ONE,2015,10(2).
APA Chen, Yi,Feng, Jing,Gilbert, Clare,Yin, Hong,Liang, Jianhong,&Li, Xiaoxin.(2015).Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants.PLOS ONE,10(2).
MLA Chen, Yi,et al."Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants".PLOS ONE 10.2(2015).
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