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学科主题: 临床医学
题名:
Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants
作者: Chen, Yi1,2; Feng, Jing1,2; Gilbert, Clare3; Yin, Hong1,2; Liang, Jianhong1,2; Li, Xiaoxin1,2
刊名: PLOS ONE
发表日期: 2015-02-09
DOI: 10.1371/journal.pone.0116669
卷: 10, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: THRESHOLD RETINOPATHY ; MULTICENTER TRIAL ; COUNTRIES ; CRYOTHERAPY ; OUTCOMES ; AGE
英文摘要:

Purpose

To investigate the postmenstrual (PMA) age at treatment of severe retinopathy of prematurity (i.e. Type 1 prethreshold or threshold) in infants in a tertiary referral center in China.

Principal Findings

76.6% (359/469) of infants were treated for threshold disease. 67.5% (317/469) of infants had a birth weight (BW) of 1250g or above and almost 30% (126) had a gestational age (GA) of 32 weeks or above. There was little difference in the characteristics of infants treated for Type 1 prethreshold or threshold ROP. After controlling for GA, PMA age at treatment was highest in infants with BW >= 2000g (mean PMA 40.3 +/- 4.4 weeks, p<0.001); after controlling for BW, higher GA was associated with higher PMA at treatment (mean PMA 41.5 weeks for gestational age >34 weeks, p<0.001). For every three weeks increase in GA there was a two-week increase in PMA at treatment (R2 = 0.20, p<0.001). The time at treatment of Type 1 prethreshold disease was similar to that for threshold disease i.e. chronological age 5.6-7.4 weeks, or PMA 34.1-40.2 weeks but the lower end of the 95% confidence interval for chronological age for Type 1 prethreshold disease among infants with BW >= 2000g was 3.7 weeks (i.e. before the recommended interval of 4-6 weeks after birth).

Significance

The Chinese guidelines regarding timing of the first examination are appropriate for infants with BW <2000g, but more mature infants should be examined a little earlier, at 3 weeks after birth, in order to detect Type 1 prethreshold disease which has a better prognosis than threshold.

语种: 英语
WOS记录号: WOS:000349123100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50729
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
3.London Sch Hyg & Trop Med, Dept Clin Res, Int Ctr Eye Hlth, London WC1, England

Recommended Citation:
Chen, Yi,Feng, Jing,Gilbert, Clare,et al. Time at Treatment of Severe Retinopathy of Prematurity in China: Recommendations for Guidelines in More Mature Infants[J]. PLOS ONE,2015,10(2).
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