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In Vitro and In Vivo Study of Gal-OS Self-Assembled Nanoparticles for Liver-Targeting Delivery of Doxorubicin
Guo, Hejian1; Zhang, Dianrui1; Li, Tingting1; Li, Caiyun1; Guo, Yuanyuan1; Liu, Guangpu1; Hao, Leilei1; Shen, Jingyi1; Qi, Lisi1; Liu, Xinquan1; Luan, Jingjing1; Zhang, Qiang2
关键词Nanoparticles Drug Targeting Drug Delivery Systems Pharmacodynamics Pharmacokinetics O-carboxymethyl Chitosan Liver Targeting Tissue Distribution Doxorubicin
刊名JOURNAL OF PHARMACEUTICAL SCIENCES
2014-03-01
DOI10.1002/jps.23875
103期:3页:987-993
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
资助者National Basic Research Programme of China (973 Programme) ; National Basic Research Programme of China (973 Programme)
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]DRUG-DELIVERY ; MICELLES ; CYTOTOXICITY ; CONJUGATE
英文摘要

A liver-targeting drug delivery system for doxorubicin (DOX), that is, DOX-loaded self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates (Gal-OS/DOX), has been prepared. The objective of the present study was to investigate the preparation, in vitro release, in vivo pharmacokinetics, and tissue distribution of Gal-OS/DOX nanoparticles. The drug-loaded nanoparticles were spherical in shape with mean size of 181.9nm. In vitro release profiles indicated that the release of DOX from Gal-OS/DOX nanoparticles behaved with a sustained and pH-dependent drug release. Pharmacokinetics study revealed Gal-OS/DOX nanoparticles exhibited a higher AUC value and a prolonged residence time of drug in the blood circulation than those of DOX solution. Furthermore, Gal-OS/DOX nanoparticles increased the uptake of DOX in liver and spleen, but decreased uptake in heart, lung, and kidney in the tissue distribution study. These results suggested that the Gal-OS/DOX nanoparticles could prolong blood circulation time, enhance the liver accumulation, and reduce the side effect especially the cardiotoxicity of DOX. In conclusion, Gal-OS/DOX nanoparticles could be a promising drug delivery system for liver cancer therapy. (c) 2014 Wiley Periodicals, Inc.

语种英语
所属项目编号2009CB930300
资助者National Basic Research Programme of China (973 Programme) ; National Basic Research Programme of China (973 Programme)
WOS记录号WOS:000331392900022
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50733
专题北京大学药学院
作者单位1.Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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Guo, Hejian,Zhang, Dianrui,Li, Tingting,et al. In Vitro and In Vivo Study of Gal-OS Self-Assembled Nanoparticles for Liver-Targeting Delivery of Doxorubicin[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2014,103(3):987-993.
APA Guo, Hejian.,Zhang, Dianrui.,Li, Tingting.,Li, Caiyun.,Guo, Yuanyuan.,...&Zhang, Qiang.(2014).In Vitro and In Vivo Study of Gal-OS Self-Assembled Nanoparticles for Liver-Targeting Delivery of Doxorubicin.JOURNAL OF PHARMACEUTICAL SCIENCES,103(3),987-993.
MLA Guo, Hejian,et al."In Vitro and In Vivo Study of Gal-OS Self-Assembled Nanoparticles for Liver-Targeting Delivery of Doxorubicin".JOURNAL OF PHARMACEUTICAL SCIENCES 103.3(2014):987-993.
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