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学科主题: 药学
题名:
Self-assembly and Mechanism of Surfactant-like Peptide A(6)KA(6)K
作者: Ma Xin1; Meng Qing-Bin2,3; Kou Ying-Ying2; Liang Yuan-Jun2; Guo Lei2; Ni Cai-Hua1; Liu Ke-Liang2
关键词: Surfactant-like peptide ; Self-assembly ; Fluorescence probe ; Nanovesicle
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2011-08-10
卷: 32, 期:8, 页:1774-1778
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: HELIX PROPENSITY
英文摘要:

A diploid A(6)KA(6)K of surfactant-like peptide A(6)K was designed to study the influence on the length and ratio of the hydrophilic and hydrophobic segments in the peptide self-assembly. The secondary structure of the A(6)KA(6)K was mainly random coil and minor alpha-helix, which was characterized by circular dichroism. The results observed by transmission electron microscopy and dynamic light scattering revealed that the peptide could self-assemble to form nanovesicles in aqueous solution. Pyrene probe fluorescence analysis indicated this peptide could form hydrophobic domains in which pyrene molecules were imbedded and undergo self-assembly in the form of micelles. The critical micelle concentration of the peptide was also calculated. Compared with the surfactant peptide A(6)K reported previously, the longer peptide A(6)KA(6)K containing 14 amino acids could form nanovesicles through self-assembly, because the introduction of a hydrophilic amino acid into the hydrophobic segment of the peptide influenced the hydrophobic interaction of the peptide.

语种: 中文
WOS记录号: WOS:000294578000023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50736
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China
2.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Ma Xin,Meng Qing-Bin,Kou Ying-Ying,et al. Self-assembly and Mechanism of Surfactant-like Peptide A(6)KA(6)K[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2011,32(8):1774-1778.
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