北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A
作者: Dai, JD1; Nagai, T1; Wang, XQ1; Zhang, T1; Meng, M1; Zhang, Q1
关键词: cyclosporine A ; pH-sensitive naroparticles ; poly(methacrylic acid and methacrylate) copolymer ; neoral microemulsion ; in vitro ; release ; oral bioavailability
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2004-08-06
DOI: 10.1016/j.ijpharm.2004.05.006
卷: 280, 期:1-2, 页:229-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRUG-RELEASE ; POLYCAPROLACTONE NANOPARTICLES ; INTRAINDIVIDUAL VARIABILITY ; MICROSPHERES ; ABSORPTION ; EMULSION ; DELIVERY ; RAT ; GLYCOPROTEIN ; NANOCAPSULES
英文摘要:

The purpose of this work was to improve the oral bioavailability of cyclosporine A (CyA) by preparation the CyA-pH sensitive nanoparticles. The CyA-pH sensitive nanoparticles were prepared by using poly(methacrylic acid and methacrylate) copolymer. The characterization and the dispersion state of CyA at the surface or inside the polymeric matrices of the nanoparticles were investigated. The in vitro release studies were conducted by ultracentrifuge method. The bioavailability of CyA from nanoparticles and Neoral microemulsion was assessed in Sprague-Dawley (SD) rats at a dose of 15 mg/kg. The particle size of the nanoparticles was within the range from 37.4 +/- 5.6 to 106.7 +/- 14.8 nm. The drug entrapped efficiency was very high (from 90.9 to 99.9%) and in all cases the drug was amorphous or molecularly dispersed within the nanoparticles polymeric matrices. In vitro release experiments revealed that the nanoparticles exhibited perfect pH-dependant release profiles. The relative bioavailability of CyA was markedly increased by 32.5% for CyA-S100 nanoparticles (P < 0.05), and by 15.2% and 13.6% for CyA-L100-55 and CyA-L100 nanoparticles respectively, while it was decreased by 5.2% from CyA-E100 nanoparticles when compared with the Neoral microemulsion. With these results, the potential of pH-sensitive nanoparticles for the oral delivery of CyA was confirmed. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000223453200021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50737
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hoshi Univ, Dept Pharmaceut, Tokyo 1420063, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
3.N China Pharmacet Grp Co Ltd, Inst Pharmaceut, Shijiazhuang, Peoples R China

Recommended Citation:
Dai, JD,Nagai, T,Wang, XQ,et al. pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2004,280(1-2):229-240.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dai, JD]'s Articles
[Nagai, T]'s Articles
[Wang, XQ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dai, JD]‘s Articles
[Nagai, T]‘s Articles
[Wang, XQ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace