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IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
PROGNOSTIC VALUE OF SERUM VON WILLEBRAND FACTOR, BUT NOT SOLUBLE ICAM AND VCAM, FOR MORTALITY AND CARDIOVASCULAR EVENTS IS INDEPENDENT OF RESIDUAL RENAL FUNCTION IN PERITONEAL DIALYSIS PATIENTS
作者: Dong, Jie1; Li, Yan-Jun1; Yang, Zhi-Kai1; Xu, Rong1
关键词: Cardiovascular mortality ; soluble intercellular adhesion molecule 1 ; sICAM ; soluble vascular adhesion molecule 1 ; sVCAM ; von Willebrand factor ; vWf
刊名: PERITONEAL DIALYSIS INTERNATIONAL
发表日期: 2014-11-01
DOI: 10.3747/pdi.2012.00004
卷: 34, 期:7, 页:706-713
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; CELL-ADHESION MOLECULE-1 ; CORONARY-HEART-DISEASE ; C-REACTIVE PROTEIN ; ENDOTHELIAL DYSFUNCTION ; HEMODIALYSIS-PATIENTS ; ATHEROSCLEROSIS RISK ; PLASMA-CONCENTRATION ; HEMOSTATIC FACTORS ; INFLAMMATION
英文摘要:

Objective: We explored associations between markers of endothelial dysfunction and outcome events, and whether those associations were independent of residual renal function (RRF) in patients on peritoneal dialysis.

Methods: The study enrolled 261 incident patients and 68 healthy control subjects who were followed till death, censoring, or study end. Demographics, biochemistry, markers of inflammation (C-reactive protein) and endothelial dysfunction [soluble intercellular adhesion molecule 1 (sICAM), soluble vascular adhesion molecule 1 (sVCAM), and von Willebrand factor (vWf)] were examined at baseline. Outcome events included all-cause death and fatal and nonfatal cardiovascular (CV) events.

Results: Mean levels of vWf, sICAM, and sVCAM were significantly higher in patients than in healthy control subjects. Levels of sICAM and sVCAM, but not vWf, were significantly correlated with RRF. Levels of sICAM and vWf both predicted all-cause mortality and fatal and nonfatal CV events after adjustment for recognizable CV risk factors. The association between sICAM and outcome events disappeared after further adjustment for RRF. However, RRF did not change the predictive role of vWf for outcome events. Compared with the lowest vWf quartile (6.6%-73.9%), the highest vWf quartile (240.9%-1161%) predicted the highest risk for fatal and nonfatal CV events (adjusted hazard ratio: 2.05; 95% confidence interval: 1.15 to 3.64; p = 0.014). We observed no associations between sVCAM and RRF, or sVCAM and any outcome event.

Conclusions: The prognostic value of vWf, but not sICAM, is independent of RRF in predicting mortality and CV events.

语种: 英语
所属项目编号: Z111107058811110
项目资助者: Capital Characteristic Clinic Research Grant from the Beijing Science and Technology Committee ; New Century Excellent Talents grant from the Education Department of China ; Clinical Research Award from the International Society of Nephrology GO RP Committee ; Ketosteril Research Award from Fresenius Kabi Deutschland ; Clinical Research Award from Baxter Healthcare Corporation, China
WOS记录号: WOS:000346465800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50738
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100034, Peoples R China

Recommended Citation:
Dong, Jie,Li, Yan-Jun,Yang, Zhi-Kai,et al. PROGNOSTIC VALUE OF SERUM VON WILLEBRAND FACTOR, BUT NOT SOLUBLE ICAM AND VCAM, FOR MORTALITY AND CARDIOVASCULAR EVENTS IS INDEPENDENT OF RESIDUAL RENAL FUNCTION IN PERITONEAL DIALYSIS PATIENTS[J]. PERITONEAL DIALYSIS INTERNATIONAL,2014,34(7):706-713.
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