IR@PKUHSC  > 北京大学药学院  > 化学生物学系
学科主题药学
Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells
Zhang, Ying1; Fu, Li-Juan1; Li, Jin-Xia1; Yang, Xiao-Gai1; Yang, Xiao-Da1,2; Wang, Kui1,2
关键词Gadolinium Proliferation Cell Cycle Survival
刊名BIOMETALS
2009-06-01
DOI10.1007/s10534-009-9208-5
22期:3页:511-519
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]FOCAL ADHESION KINASE ; MOTEXAFIN GADOLINIUM ; LANTHANUM CARBONATE ; MELANOMA-CELLS ; NIH 3T3-CELLS ; CANCER-CELLS ; APOPTOSIS ; PROTEIN ; MACROPHAGES ; PATHWAY
英文摘要

The effect of gadolinium chloride (Gd) on the proliferation of HeLa cells was investigated at lower concentration. The results obtained by MTT and cell cycle analysis showed that Gd promoted proliferation by inducing S phase entry in HeLa cells at the concentration less than 100 mu M. It was further evidenced by both an increase in the levels of phosphorylation of retinoblastoma protein (pRb) and a remarkable increase in cyclin E expression. Moreover, the survival of cells, exposed to Gd up to 3-5 days, was increased compared with control. The attenuation of the serum deprivation-induced cell loss by Gd was associated with the sustained activation of FAK (PY(397)) and the delayed activation of JNKs pathway. Besides, it appeared that Gd promoted cell proliferation and survival in HeLa cells was not contributed to the ROS generation. Based on the present results, both positive and negative effects of the lanthanides as potential drugs or diagnostic agents are discussed.

语种英语
WOS记录号WOS:000266074400011
项目编号20637010
资助机构National Natural Science Foundation of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50759
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Natl Res Labs Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Ying,Fu, Li-Juan,Li, Jin-Xia,et al. Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells[J]. BIOMETALS,2009,22(3):511-519.
APA Zhang, Ying,Fu, Li-Juan,Li, Jin-Xia,Yang, Xiao-Gai,Yang, Xiao-Da,&Wang, Kui.(2009).Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells.BIOMETALS,22(3),511-519.
MLA Zhang, Ying,et al."Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells".BIOMETALS 22.3(2009):511-519.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Ying]的文章
[Fu, Li-Juan]的文章
[Li, Jin-Xia]的文章
百度学术
百度学术中相似的文章
[Zhang, Ying]的文章
[Fu, Li-Juan]的文章
[Li, Jin-Xia]的文章
必应学术
必应学术中相似的文章
[Zhang, Ying]的文章
[Fu, Li-Juan]的文章
[Li, Jin-Xia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。