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学科主题: 药学
题名:
Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells
作者: Zhang, Ying1; Fu, Li-Juan1; Li, Jin-Xia1; Yang, Xiao-Gai1; Yang, Xiao-Da1,2; Wang, Kui1,2
关键词: Gadolinium ; Proliferation ; Cell cycle ; Survival
刊名: BIOMETALS
发表日期: 2009-06-01
DOI: 10.1007/s10534-009-9208-5
卷: 22, 期:3, 页:511-519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: FOCAL ADHESION KINASE ; MOTEXAFIN GADOLINIUM ; LANTHANUM CARBONATE ; MELANOMA-CELLS ; NIH 3T3-CELLS ; CANCER-CELLS ; APOPTOSIS ; PROTEIN ; MACROPHAGES ; PATHWAY
英文摘要:

The effect of gadolinium chloride (Gd) on the proliferation of HeLa cells was investigated at lower concentration. The results obtained by MTT and cell cycle analysis showed that Gd promoted proliferation by inducing S phase entry in HeLa cells at the concentration less than 100 mu M. It was further evidenced by both an increase in the levels of phosphorylation of retinoblastoma protein (pRb) and a remarkable increase in cyclin E expression. Moreover, the survival of cells, exposed to Gd up to 3-5 days, was increased compared with control. The attenuation of the serum deprivation-induced cell loss by Gd was associated with the sustained activation of FAK (PY(397)) and the delayed activation of JNKs pathway. Besides, it appeared that Gd promoted cell proliferation and survival in HeLa cells was not contributed to the ROS generation. Based on the present results, both positive and negative effects of the lanthanides as potential drugs or diagnostic agents are discussed.

语种: 英语
所属项目编号: 20637010
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000266074400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50759
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Natl Res Labs Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Ying,Fu, Li-Juan,Li, Jin-Xia,et al. Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells[J]. BIOMETALS,2009,22(3):511-519.
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