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Efficacy of acupuncture for migraine prophylaxis: A single-blinded, double-dummy, randomized controlled trial
Wang, Lin-Peng1; Zhang, Xiao-Zhe2; Guo, Jia3; Liu, Hui-Lin1; Zhang, Yan4; Liu, Cun-Zhi1; Yi, Jing-Hong1; Wang, Li-Ping5; Zhao, Ji-Ping6; Li, Shan-Shan1
关键词Migraine Acupuncture Prophylaxis Treatment Flunarizine
刊名PAIN
2011-08-01
DOI10.1016/j.pain.2011.04.006
152期:8页:1864-1871
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]MEDICATION-OVERUSE-HEADACHE ; CLINICAL-TRIALS ; 2ND EDITION ; PREVALENCE ; FLUNARIZINE ; PAIN
英文摘要

Insufficient clinical trial data were available to prove the efficacy of acupuncture for migraine prophylaxis. A multicenter, double-dummy, single-blinded, randomized controlled clinical trial was conducted at the outpatient departments of acupuncture at 5 hospitals in China to evaluate the effectiveness of acupuncture. A total of 140 patients with migraine without aura were recruited and assigned randomly to 2 different groups: the acupuncture group treated with verum acupuncture plus placebo and the control group treated with sham acupuncture plus flunarizine. Treated by acupuncture 3 times per week and drugs every night, patients from both groups were evaluated at week 0 (baseline), week 4, and week 16. The primary outcome was measured by the proportion of responders (defined as the proportion of patients with a reduction of migraine days by at least 50%). The secondary outcome measures included the number of migraine days, visual analogue scale (VAS, 0 to 10 cm) for pain, as well as the physical and mental component summary scores of the 36-item short-form health survey (SF-36). The patients in the acupuncture group had better responder rates and fewer migraine days compared with the control group (P < .05), whereas there were no significant differences between the 2 groups in VAS scores and SF-36 physical and mental component summary scores (P > .05). The results suggested that acupuncture was more effective than flunarizine in decreasing days of migraine attacks, whereas no significantly differences were found between acupuncture and flunarizine in reduction of pain intensity and improvement of the quality of life. (C) 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000292862400027
项目编号SF-2005-2
资助机构Capital Medical Development Research Fund
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50763
专题北京大学第三临床医学院
作者单位1.Capital Med Univ, Acupuncture & Moxibust Dept, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China
2.Capital Med Univ, Acupuncture & Moxibust Dept, Beijing Tiantan Hosp, Beijing, Peoples R China
3.Peking Univ, Acupuncture & Moxibust Dept, Hosp 3, Beijing 100871, Peoples R China
4.Quintiles Med Dev Shanghai Co Ltd, Beijing Branch, Beijing, Peoples R China
5.Beijing Univ Chinese Med, Acupuncture & Moxibust Dept, Huguosi Hosp, Beijing, Peoples R China
6.Beijing Univ Chinese Med, Acupuncture & Moxibust Dept, Dongzhimen Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Lin-Peng,Zhang, Xiao-Zhe,Guo, Jia,et al. Efficacy of acupuncture for migraine prophylaxis: A single-blinded, double-dummy, randomized controlled trial[J]. PAIN,2011,152(8):1864-1871.
APA Wang, Lin-Peng.,Zhang, Xiao-Zhe.,Guo, Jia.,Liu, Hui-Lin.,Zhang, Yan.,...&Li, Shan-Shan.(2011).Efficacy of acupuncture for migraine prophylaxis: A single-blinded, double-dummy, randomized controlled trial.PAIN,152(8),1864-1871.
MLA Wang, Lin-Peng,et al."Efficacy of acupuncture for migraine prophylaxis: A single-blinded, double-dummy, randomized controlled trial".PAIN 152.8(2011):1864-1871.
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