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Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus
Ge, Y1; Tsukatani, T1; Nishimura, T1; Furukawa, M1; Miwa, T1
刊名CHEMICAL SENSES
2002-07-01
27期:6页:521-527
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Food Science & Technology ; Neurosciences ; Physiology
研究领域[WOS]Behavioral Sciences ; Food Science & Technology ; Neurosciences & Neurology ; Physiology
关键词[WOS]EPITHELIUM
英文摘要

Nasosinusitis is a common cause of acquired hyposmia or anosmia. To study the apoptotic death of olfactory receptor neurons in nasosinusitis, we made an inflammation model in rat infected with Staphylococcus. The histochemical changes in olfactory epithelium were examined using antibodies against protein gene product 9.5 (PGP 9.5), single-strand DNA (ssDNA), Bcl-2 and Bax that might be involved in the apoptosis of olfactory receptor neurons. The thickness of olfactory epithelium and the number of ssDNA-labeled cells were evaluated in each post-treatment group and the results were analyzed by two-way analysis of variance (ANOVA) and post hoc tests. Hematoxylin-eosin staining showed that a severe inflammatory reaction had occurred on the infected side of the nasal cavity and sinus, but not on the non-infected side. However, apoptosis of olfactory receptor neurons occurred on both sides; the apoptosis on the non-infected side started later and behaved like a shadow curve similarly to the infected side. Repeated measures ANOVA showed significant differences of both the thickness of olfactory epithelium (P < 0.0001) and the number of ssDNA-labeled cells (P = 0.0339) in the epithelium between the infected side and non-infected side comparing treatment, time and their interactions. Bcl-2 and Bax were detected only on the infected side in the early stages. Thus, nasosinusitis induced the apoptosis of olfactory receptor neurons. However, the apoptosis occurred not only on the infected side, but also on the non-infected side with no significant inflammation. The Bcl-2/Bax family seems to play an important role in the apoptosis induced by infection, but not in the apoptosis on the non-infected side. The results suggest that mechanisms of apoptosis of olfactory receptor neurons on the infected side may differ from those on the non-infected side.

语种英语
WOS记录号WOS:000177055600005
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50766
专题北京大学第二临床医学院
北京大学口腔医学院_第二门诊部
作者单位1.Beijing Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Kanazawa Univ, Grad Sch Med Sci, Dept Otorhinolaryngol, Kanazawa, Ishikawa 9208641, Japan
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Ge, Y,Tsukatani, T,Nishimura, T,et al. Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus[J]. CHEMICAL SENSES,2002,27(6):521-527.
APA Ge, Y,Tsukatani, T,Nishimura, T,Furukawa, M,&Miwa, T.(2002).Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus.CHEMICAL SENSES,27(6),521-527.
MLA Ge, Y,et al."Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus".CHEMICAL SENSES 27.6(2002):521-527.
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