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学科主题基础医学
Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB
Xu, Ying; Ku, Baoshan; Tie, Lu; Yao, Haiyan; Jiang, Wengao; Ma, Xing; Li, Xuejun
关键词Curcumin Depression Chronic Unpredictable Stress Hpa Axis Shuttle Box Gr Bdnf Pcreb/creb Rat
刊名BRAIN RESEARCH
2006-11-29
DOI10.1016/j.brainres.2006.09.009
1122页:56-64
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CHRONIC VARIABLE STRESS ; PITUITARY-ADRENAL AXIS ; RECEPTOR MESSENGER-RNA ; ANIMAL-MODEL ; LEARNED HELPLESSNESS ; DEPRESSION ; RATS ; ANTIDEPRESSANTS ; IMIPRAMINE ; BRAIN
英文摘要

Curcuma longa is a major constituent of the traditional Chinese medicine Xiaoyao-san, which has been used to effectively manage stress and depression-related disorders in China. Curcumin is the active component of curcuma longa, and its antidepressant effects were described in our prior studies in mouse models of behavioral despair. We hypothesized that curcumin may also alleviate stress-induced depressive-like behaviors and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Thus in present study we assessed whether curcumin treatment (2.5, 5 and 10 mg/kg, p.o.) affects behavior in a chronic unpredictable stress model of depression in rats and examined what its molecular targets may be. We found that subjecting animals to the chronic stress protocol for 20 days resulted in performance deficits in the shuttle-box task and several physiological effects, such as an abnormal adrenal gland weight to body weight (AG/B) ratio and increased thickness of the adrenal cortex as well as elevated serum corticosterone levels and reduced glucocorticoid receptor (GR) mRNA expression. These changes were reversed by chronic curcumin administration (5 or 10 mg/kg, p.o.). In addition, we also found that the chronic stress procedure induced a down-regulation of brain-derived neurotrophic factor (BDNF) protein levels and reduced the ratio of phosphorylated cAMP response element-binding protein (pCREB) to CREB levels (pCREB/CREB) in the hippocampus and frontal cortex of stressed rats. Furthermore, these stress-induced decreases in BDNF and pCREB/CREB were also blocked by chronic curcumin administration (5 or 10 mg/kg, p.o.). These results provide compelling evidence that the behavioral effects of curcumin in chronically stressed animals, and by extension humans, may be related to their modulating effects on the HPA axis and neurotrophin factor expressions. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000242668500008
引用统计
被引频次:147[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50769
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
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Xu, Ying,Ku, Baoshan,Tie, Lu,et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB[J]. BRAIN RESEARCH,2006,1122:56-64.
APA Xu, Ying.,Ku, Baoshan.,Tie, Lu.,Yao, Haiyan.,Jiang, Wengao.,...&Li, Xuejun.(2006).Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.BRAIN RESEARCH,1122,56-64.
MLA Xu, Ying,et al."Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB".BRAIN RESEARCH 1122(2006):56-64.
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