北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways
作者: Wang, GM; Feng, YG; Hao, J; Li, AL; Gao, X; Xie, SS
关键词: CD28-B7 ; OX40-OX40L ; streptozotocin ; adenovirus ; islet transplantation ; type 1 diabetes mellitus
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2005-10-01
DOI: 10.1360/062004-127
卷: 48, 期:5, 页:515-522
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: CARDIAC ALLOGRAFT ; GENE RESULT ; SURVIVAL ; ADENOVIRUS ; CTLA4IG ; OX40 ; EXPRESSION ; XENOGRAFT
英文摘要:

It has been demonstrated that prolonged graft survival can be achieved through inhibiting the activation of T cells, and addition of soluble CTLA4lg and OX40 vertical bar g proteins to mixed lymphocyte reactions can effectively inhibit T cell proliferation. To explore the potential of this type of treatment in xenotransplantation, we infected streptozotocin-induced diabetic BaIB/c mice (H-2d) (200 mg/kg, IV) with 5x10(8) pfu AdCTLA4lg-IRES-OX40lg on day 1 before islets transplantation through the tail vein. The results showed that this treatment prolonged the islet xenografts survival significantly. The reaction to exogenous glucose stimulation was normal and the cytokine secretion of the type Th1 cells was inhibited. The AdCTLA4lg-IRES-OX40lg-mediated treatment effectively induced the T cells into anergy and the Th1/Th2 cells into deviation. These results strongly supported the therapeutic potential of blockade of costimulation by AdCTLA4lg-IRES-OX40lg genes transfer in inducing the organ transplantation tolerance.

语种: 英语
WOS记录号: WOS:000233343900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50775
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, GM,Feng, YG,Hao, J,et al. Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2005,48(5):515-522.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, GM]'s Articles
[Feng, YG]'s Articles
[Hao, J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, GM]‘s Articles
[Feng, YG]‘s Articles
[Hao, J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace