IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways
Wang, GM; Feng, YG; Hao, J; Li, AL; Gao, X; Xie, SS
关键词Cd28-b7 Ox40-ox40l Streptozotocin Adenovirus Islet Transplantation Type 1 Diabetes Mellitus
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2005-10-01
DOI10.1360/062004-127
48期:5页:515-522
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]CARDIAC ALLOGRAFT ; GENE RESULT ; SURVIVAL ; ADENOVIRUS ; CTLA4IG ; OX40 ; EXPRESSION ; XENOGRAFT
英文摘要

It has been demonstrated that prolonged graft survival can be achieved through inhibiting the activation of T cells, and addition of soluble CTLA4lg and OX40 vertical bar g proteins to mixed lymphocyte reactions can effectively inhibit T cell proliferation. To explore the potential of this type of treatment in xenotransplantation, we infected streptozotocin-induced diabetic BaIB/c mice (H-2d) (200 mg/kg, IV) with 5x10(8) pfu AdCTLA4lg-IRES-OX40lg on day 1 before islets transplantation through the tail vein. The results showed that this treatment prolonged the islet xenografts survival significantly. The reaction to exogenous glucose stimulation was normal and the cytokine secretion of the type Th1 cells was inhibited. The AdCTLA4lg-IRES-OX40lg-mediated treatment effectively induced the T cells into anergy and the Th1/Th2 cells into deviation. These results strongly supported the therapeutic potential of blockade of costimulation by AdCTLA4lg-IRES-OX40lg genes transfer in inducing the organ transplantation tolerance.

语种英语
WOS记录号WOS:000233343900012
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50775
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学药学院_药物化学系
北京大学第三临床医学院_泌尿外科
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Wang, GM,Feng, YG,Hao, J,et al. Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2005,48(5):515-522.
APA Wang, GM,Feng, YG,Hao, J,Li, AL,Gao, X,&Xie, SS.(2005).Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,48(5),515-522.
MLA Wang, GM,et al."Induction of xenogeneic islet transplantation tolerance by simultaneously blocking CD28-B7 and OX40-OX40L co-stimulatory pathways".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 48.5(2005):515-522.
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