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学科主题: 临床医学
题名:
Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis
作者: Yu, Xiaoyong1; Gan, Liangying2; Wang, Zhaohui3; Dong, Bao2; Chen, Xiaohong1
关键词: acute kidney injury ; meta-analysis ; multiple myeloma ; plasmapheresis
刊名: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
发表日期: 2015-05-01
DOI: 10.5414/CP202245
卷: 53, 期:5, 页:391-397
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: LIGHT-CHAIN REMOVAL ; PLASMA-EXCHANGE ; CAST NEPHROPATHY ; KIDNEY ; HEMODIALYSIS ; PATHOGENESIS ; MANAGEMENT ; DIAGNOSIS ; TRIAL
英文摘要:

Background/Aim: The clinical benefits of plasmapheresis in the management of multiple myeloma-induced acute renal failure remain controversial. In this study, we conducted a meta-analysis to quantitatively evaluate the clinical efficacy of chemotherapy with or without plasmapheresis in the treatment of multiple myeloma patients with renal failure. Methods: Randomized controlled trials evaluating clinical efficacy of plasmapheresis were identified by searching PubMed (from 1980 to November 2013) and EMBASE (from 1980 to November 2013). Outcomes subjected to meta-analysis were 6-month survival and dialysis-dependent rate. Results: Three randomized controlled studies were selected for meta-analysis. A total of 63 patients received chemotherapy only and 84 patients were given both chemotherapy and plasmapheresis. No difference was observed in 6-month survival rate between plasmapheresis and control group (75% vs. 66.7%; risk ratio, 0.92; 95% CI, 0.76 - 1.11; p = 0.39). 6-month dialysis-dependent ratio was significantly lower in patients treated, with both chemotherapy and plasmapheresis than chemotherapy only (15.6% vs. 37.2%; risk ratio, 2.02; 95% CI, 1.03 - 3.96; p = 0.04). Conclusion: Our meta-analysis results showed that plasmapheresis used as an adjunct to chemotherapy had a benefit in the management of dialysis-dependent multiple myeloma patients with renal failure.

语种: 英语
WOS记录号: WOS:000355495400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50782
Appears in Collections:北京大学第二临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
2.Shanxi Prov Hosp Tradit Chinese Med, Dept Nephrol, Xian 71003, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Ruijin Hosp, Sch Med, Dept Nephrol, Shanghai 200030, Peoples R China

Recommended Citation:
Yu, Xiaoyong,Gan, Liangying,Wang, Zhaohui,et al. Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2015,53(5):391-397.
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