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Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis
Yu, Xiaoyong1; Gan, Liangying2; Wang, Zhaohui3; Dong, Bao2; Chen, Xiaohong1
关键词Acute Kidney Injury Meta-analysis Multiple Myeloma Plasmapheresis
刊名INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
2015-05-01
DOI10.5414/CP202245
53期:5页:391-397
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]LIGHT-CHAIN REMOVAL ; PLASMA-EXCHANGE ; CAST NEPHROPATHY ; KIDNEY ; HEMODIALYSIS ; PATHOGENESIS ; MANAGEMENT ; DIAGNOSIS ; TRIAL
英文摘要

Background/Aim: The clinical benefits of plasmapheresis in the management of multiple myeloma-induced acute renal failure remain controversial. In this study, we conducted a meta-analysis to quantitatively evaluate the clinical efficacy of chemotherapy with or without plasmapheresis in the treatment of multiple myeloma patients with renal failure. Methods: Randomized controlled trials evaluating clinical efficacy of plasmapheresis were identified by searching PubMed (from 1980 to November 2013) and EMBASE (from 1980 to November 2013). Outcomes subjected to meta-analysis were 6-month survival and dialysis-dependent rate. Results: Three randomized controlled studies were selected for meta-analysis. A total of 63 patients received chemotherapy only and 84 patients were given both chemotherapy and plasmapheresis. No difference was observed in 6-month survival rate between plasmapheresis and control group (75% vs. 66.7%; risk ratio, 0.92; 95% CI, 0.76 - 1.11; p = 0.39). 6-month dialysis-dependent ratio was significantly lower in patients treated, with both chemotherapy and plasmapheresis than chemotherapy only (15.6% vs. 37.2%; risk ratio, 2.02; 95% CI, 1.03 - 3.96; p = 0.04). Conclusion: Our meta-analysis results showed that plasmapheresis used as an adjunct to chemotherapy had a benefit in the management of dialysis-dependent multiple myeloma patients with renal failure.

语种英语
WOS记录号WOS:000355495400006
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50782
专题北京大学第二临床医学院_肾内科
作者单位1.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China
2.Shanxi Prov Hosp Tradit Chinese Med, Dept Nephrol, Xian 71003, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Ruijin Hosp, Sch Med, Dept Nephrol, Shanghai 200030, Peoples R China
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Yu, Xiaoyong,Gan, Liangying,Wang, Zhaohui,et al. Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2015,53(5):391-397.
APA Yu, Xiaoyong,Gan, Liangying,Wang, Zhaohui,Dong, Bao,&Chen, Xiaohong.(2015).Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis.INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,53(5),391-397.
MLA Yu, Xiaoyong,et al."Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis".INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 53.5(2015):391-397.
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