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学科主题: 临床医学
题名:
A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review
作者: Liu Hongyan1; Zheng Yi1; Dong Bao2; Lu Yuewu1; Meng Juan1
刊名: CLINICAL & DEVELOPMENTAL IMMUNOLOGY
发表日期: 2013
DOI: 10.1155/2013/289316
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: ERYTHEMATOSUS ; NEPHROPATHY ; CLASSIFICATION ; PATIENT
英文摘要:

Objective. To study the clinical and pathologic features of systemic lupus erythematosus (SLE) that has atypical lupus nephritis (LN) with mainly IgA deposits. Methods. We searched the SLE patients who had nephritis with mainly IgA deposits in our hospital and selected the information including clinical manifestations, laboratory tests, treatments, and prognosis. Results. From January 2009 to June 2012, 5 patients were definitely diagnosed as SLE according to both 1982 and 2009 ACR classification criteria. But renal biopsy showed that all cases had mainly IgA deposits and were free of IgG, C1q, and fibrinogen-related antigen deposits under immunofluorescent microscopy, which did not match with typical LN. There were 2 males and 3 females, aging from 31 to 64 years and with an average of (42.20 +/- 13.59) years. The 5 cases had multiple-system involvements, mainly the renal system. Compared to primary IgAN, the atypical LN showed some differences: older than primary IgAN, more women than men, no previous infection history, lower incidence of serum IgA elevation, and ACL positive rate as high as 100%. Conclusion. Nephritis with mainly IgAN deposits, as an atypical LN, may be a special subtype of SLE.

语种: 英语
WOS记录号: WOS:000325373400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50783
Appears in Collections:北京大学第二临床医学院_肾内科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Rheumatol, Beijing 100020, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China

Recommended Citation:
Liu Hongyan,Zheng Yi,Dong Bao,et al. A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
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