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学科主题临床医学
A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review
Liu Hongyan1; Zheng Yi1; Dong Bao2; Lu Yuewu1; Meng Juan1
刊名CLINICAL & DEVELOPMENTAL IMMUNOLOGY
2013
DOI10.1155/2013/289316
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ERYTHEMATOSUS ; NEPHROPATHY ; CLASSIFICATION ; PATIENT
英文摘要

Objective. To study the clinical and pathologic features of systemic lupus erythematosus (SLE) that has atypical lupus nephritis (LN) with mainly IgA deposits. Methods. We searched the SLE patients who had nephritis with mainly IgA deposits in our hospital and selected the information including clinical manifestations, laboratory tests, treatments, and prognosis. Results. From January 2009 to June 2012, 5 patients were definitely diagnosed as SLE according to both 1982 and 2009 ACR classification criteria. But renal biopsy showed that all cases had mainly IgA deposits and were free of IgG, C1q, and fibrinogen-related antigen deposits under immunofluorescent microscopy, which did not match with typical LN. There were 2 males and 3 females, aging from 31 to 64 years and with an average of (42.20 +/- 13.59) years. The 5 cases had multiple-system involvements, mainly the renal system. Compared to primary IgAN, the atypical LN showed some differences: older than primary IgAN, more women than men, no previous infection history, lower incidence of serum IgA elevation, and ACL positive rate as high as 100%. Conclusion. Nephritis with mainly IgAN deposits, as an atypical LN, may be a special subtype of SLE.

语种英语
WOS记录号WOS:000325373400001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50783
专题北京大学第二临床医学院_肾内科
作者单位1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Rheumatol, Beijing 100020, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liu Hongyan,Zheng Yi,Dong Bao,et al. A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
APA Liu Hongyan,Zheng Yi,Dong Bao,Lu Yuewu,&Meng Juan.(2013).A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review.CLINICAL & DEVELOPMENTAL IMMUNOLOGY.
MLA Liu Hongyan,et al."A Study on Clinical and Pathologic Features in Lupus Nephritis with Mainly IgA Deposits and a Literature Review".CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013).
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