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学科主题: 临床医学
题名:
Predictors of Stroke Risk in Native Chinese with Nonrheumatic Atrial Fibrillation: Retrospective Investigation of Hospitalized Patients
作者: Sun, Yihong1; Hu, Dayi1; Li, Kuibao1; Zhou, Ziqiang2
关键词: atrial fibrillation ; stroke ; risk factor ; warfarin
刊名: CLINICAL CARDIOLOGY
发表日期: 2009-02-01
DOI: 10.1002/clc.20232
卷: 32, 期:2, 页:76-81
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ANTITHROMBOTIC THERAPY ; TRIALS
英文摘要:

Background: Data on stroke risk factor profiles and atrial fibrillation (AF) for the Chinese population are sparse. This study identified risk factors for stroke among native Chinese with nonrheumatic AF.

Methods: In this retrospective investigation, patients diagnosed with nonrheumatic AF were identified from 18 hospitals in representative areas of the country, from January 2000 to April 2002, based on the medical records. All parameters relevant to AF were compared between AF patients with stroke and those without. The independent risk factors for stroke were assessed with a logistic regression analysis.

Results: Patients numbering 3,425 with AF were included, among whom 827 subjects were discharged on account of stroke. The prevalence of stroke in nonrheumatic AF patients was 24.15%. AF patients with stroke were significantly older than controls (73.31 +/- 9.18 versus 68.22 +/- 12.29 y, p<0.001) and more likely to have a history of hypertension (71.0 versus 51.6%, p<0.001) and diabetes (17.9 versus 11.1%, p = 0.001). Both, systolic and diastolic blood pressure, are significantly higher in patients with stroke. Of all the parameters of echocardiography, there was strong evidence that left atrial (LA) thrombi significantly increased risk of stroke. Patients with persistent AF were more likely to have stroke than paroxysmal AF patients, while lone AF is less in patients with stroke than in those without. The rate of anticoagulation treatment is only 9.27%, but there were no significant differences between the 2 groups. In multivariate analysis, age >= 75 y (odds ratio [OR] 1.76; 95% confidence interval [CI] 1.08-2.98), history of hypertension (OR 1.52; 95% CI 1.28-1.80), diabetes (OR 1.39; 95% CI 1.11-1.76), high systolic blood pressure (OR 1.71; 95% CI 1.21-2.28), LA thrombi (OR 2.77; 95% CI 1.25-6.13) were independent predictors for stroke.

Conclusions: The prevalence of stroke in hospitalized nonrheumatic AF patients was high. The population-specific risk factors for stroke were age >= 75 y, diabetes, history of hypertension, high systolic blood pressure and LA thrombi by transesophageal echocardiography (TEE). These merit further evaluation.

语种: 英语
WOS记录号: WOS:000263592300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50788
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Heart Ctr Peking Tongren Hosp, Beijing, Peoples R China
2.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Sun, Yihong,Hu, Dayi,Li, Kuibao,et al. Predictors of Stroke Risk in Native Chinese with Nonrheumatic Atrial Fibrillation: Retrospective Investigation of Hospitalized Patients[J]. CLINICAL CARDIOLOGY,2009,32(2):76-81.
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