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Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney
Yu, Feng; Chen, Min; Wang, Su-Xia; Zou, Wan-Zhong; Zhao, Ming-Hui; Wang, Hai-Yan
关键词Anti-neutrophil Cytoplasmic Antibodies Immune Complex Vasculitis
刊名NEPHROLOGY
2007-02-01
DOI10.1111/j.1440-1797-2006.00713.x
12期:1页:74-80
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]SMALL-VESSEL VASCULITIS ; CRESCENTIC GLOMERULONEPHRITIS ; MICROSCOPIC POLYANGIITIS ; ANCA ; MYELOPEROXIDASE ; GRANULOMATOSIS ; AUTOANTIBODIES ; POLYARTERITIS ; DETERMINANTS ; RELAPSE
英文摘要

Aim: To analyse the clinical and pathological characteristics of Chinese patients with immune complex deposition in kidney in anti-neutrophil cytoplasmic antibodies (ANCA)-positive vasculitis.

Methods: Enrolled in this study are patients with immune complex deposition in kidney in ANCA-positive vasculitis diagnosed in Peking University First Hospital. Their clinical and pathological data were collected and analysed.

Results: Twenty-three patients were eligible. Fifteen patients were with microscopic polyangiitis and eight patients were with Wegener′s granulomatosis. The mean age was 48.8 years and with a male/female ratio of 10/13. The interval, between onset of disease and the diagnosis of disease, was 429.6 +/- 693.3 days. All patients had clinical evidence of renal involvement. The major immunoglobulin deposited was IgM and the main locations were mesangial and sub-epithelial area. Four patients also presented features of membranous nephropathy and six patients presented features of IgA nephropathy. About 52.2% of patients had hypocomplementaemia. All patients received immunosuppressive therapy and all of them achieved clinical remission. Patients were followed for about 28.8 +/- 25.3 months. Nine patients kept clinical remission, nine patients progressed to end-stage renal disease and five patients died. When these patients are compared with patients who had classical pauci-immune vasculitis, they had greater proteinuria (P < 0.05), higher prevalence of hypocomplementaemia (P < 0.05) and greater glomerular cellularity (P 0.05).

Conclusion: The present study showed that the features of patients with ANCA-associated vasculitis with immune complex deposition in kidney were similar with classical ′pauci-immune′ vasculitis except for more proteinuria, more hypocomplementaemia and greater glomerular hypercellularity.

语种英语
WOS记录号WOS:000244752700014
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50789
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学第一临床医学院_电镜室
作者单位Peking Univ, Hosp 1, Div Renal, Dept Nephrol, Beijing 100034, Peoples R China
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GB/T 7714
Yu, Feng,Chen, Min,Wang, Su-Xia,et al. Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney[J]. NEPHROLOGY,2007,12(1):74-80.
APA Yu, Feng,Chen, Min,Wang, Su-Xia,Zou, Wan-Zhong,Zhao, Ming-Hui,&Wang, Hai-Yan.(2007).Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney.NEPHROLOGY,12(1),74-80.
MLA Yu, Feng,et al."Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney".NEPHROLOGY 12.1(2007):74-80.
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