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学科主题: 临床医学
题名:
Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney
作者: Yu, Feng; Chen, Min; Wang, Su-Xia; Zou, Wan-Zhong; Zhao, Ming-Hui; Wang, Hai-Yan
关键词: anti-neutrophil cytoplasmic antibodies ; immune complex ; vasculitis
刊名: NEPHROLOGY
发表日期: 2007-02-01
DOI: 10.1111/j.1440-1797-2006.00713.x
卷: 12, 期:1, 页:74-80
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SMALL-VESSEL VASCULITIS ; CRESCENTIC GLOMERULONEPHRITIS ; MICROSCOPIC POLYANGIITIS ; ANCA ; MYELOPEROXIDASE ; GRANULOMATOSIS ; AUTOANTIBODIES ; POLYARTERITIS ; DETERMINANTS ; RELAPSE
英文摘要:

Aim: To analyse the clinical and pathological characteristics of Chinese patients with immune complex deposition in kidney in anti-neutrophil cytoplasmic antibodies (ANCA)-positive vasculitis.

Methods: Enrolled in this study are patients with immune complex deposition in kidney in ANCA-positive vasculitis diagnosed in Peking University First Hospital. Their clinical and pathological data were collected and analysed.

Results: Twenty-three patients were eligible. Fifteen patients were with microscopic polyangiitis and eight patients were with Wegener′s granulomatosis. The mean age was 48.8 years and with a male/female ratio of 10/13. The interval, between onset of disease and the diagnosis of disease, was 429.6 +/- 693.3 days. All patients had clinical evidence of renal involvement. The major immunoglobulin deposited was IgM and the main locations were mesangial and sub-epithelial area. Four patients also presented features of membranous nephropathy and six patients presented features of IgA nephropathy. About 52.2% of patients had hypocomplementaemia. All patients received immunosuppressive therapy and all of them achieved clinical remission. Patients were followed for about 28.8 +/- 25.3 months. Nine patients kept clinical remission, nine patients progressed to end-stage renal disease and five patients died. When these patients are compared with patients who had classical pauci-immune vasculitis, they had greater proteinuria (P < 0.05), higher prevalence of hypocomplementaemia (P < 0.05) and greater glomerular cellularity (P 0.05).

Conclusion: The present study showed that the features of patients with ANCA-associated vasculitis with immune complex deposition in kidney were similar with classical ′pauci-immune′ vasculitis except for more proteinuria, more hypocomplementaemia and greater glomerular hypercellularity.

语种: 英语
WOS记录号: WOS:000244752700014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50789
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Div Renal, Dept Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Yu, Feng,Chen, Min,Wang, Su-Xia,et al. Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney[J]. NEPHROLOGY,2007,12(1):74-80.
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