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Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics
Zhang, Xiang Yang1,3; Zhou, Dong Feng2; Qi, Ling Yan3; Chen, Song3; Cao, Lian Yuan3; Chen, Da Chun3; Xiu, Mei Hong3; Wang, Fan3; Wu, Gui Ying1; Lu, Lin4; Kosten, Therese A.1; Kosten, Thomas R.1
关键词Schizophrenia Immune Cytokine Oxidative Stress Antioxidant Enzymes Antipsychotic Psychopathology
刊名PSYCHOPHARMACOLOGY
2009-05-01
DOI10.1007/s00213-008-1447-6
204期:1页:177-184
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
资助者Stanley Medical Institute Foundation ; Mental Illness Research, Education and Clinical Center (MIRECC) ; National Institute on Drug Abuse ; Stanley Medical Institute Foundation ; Mental Illness Research, Education and Clinical Center (MIRECC) ; National Institute on Drug Abuse
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NEUROLEPTIC-FREE SCHIZOPHRENIA ; ANTIOXIDANT DEFENSE SYSTEM ; FREE-RADICAL PATHOLOGY ; IN-VITRO PRODUCTION ; TRANSCRIPTION FACTOR ; SERUM INTERLEUKIN-6 ; TARDIVE-DYSKINESIA ; FATTY-ACIDS ; CSF LEVELS ; DRUG-FREE
英文摘要

Both schizophrenia and oxidative stress have been associated with immune system abnormalities in interleukin-2 and -6 (IL-2; IL-6) and increases in superoxide dismutase (SOD) activity. These abnormalities may improve during antipsychotic drug treatment that reduces symptoms in schizophrenic patients.

Subjects included 30 healthy controls (HC) and 78 schizophrenic (SCH) in-patients who were randomly assigned to 12 weeks of double-blind treatment with risperidone 6 mg/day or haloperidol 20 mg/day. Ratings using the Positive and Negative Syndrome Scale (PANSS) were correlated with blood SOD and serum IL-2 levels.

SCH patients who were medication-free for 2 weeks had greater SOD, IL-2, and IL-6 levels than HC. At baseline, these SOD elevations were associated with higher PANSS total scores and the IL-2 elevations with lower PANSS positive symptom scores. The SOD and IL-2 levels in the SCH were also positively correlated. After treatment, PANSS positive symptoms and both SOD and IL-2 showed a significant decrease, but IL-6 showed no change. The SOD and IL-2 reductions were correlated with the reductions in PANSS total score, and SOD reductions also correlated with positive subscore reductions. Females showed these associations more strongly than males.

Our results suggest that the dysregulation in the cytokine system and oxidative stress in patients with schizophrenia is implicated in clinical symptoms and is improved at least partially with antipsychotic treatment. The stronger associations in females deserve further study and confirmation.

语种英语
所属项目编号03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827
资助者Stanley Medical Institute Foundation ; Mental Illness Research, Education and Clinical Center (MIRECC) ; National Institute on Drug Abuse ; Stanley Medical Institute Foundation ; Mental Illness Research, Education and Clinical Center (MIRECC) ; National Institute on Drug Abuse
WOS记录号WOS:000265385700017
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50790
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing 100096, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 10083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Zhou, Dong Feng,Qi, Ling Yan,et al. Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics[J]. PSYCHOPHARMACOLOGY,2009,204(1):177-184.
APA Zhang, Xiang Yang.,Zhou, Dong Feng.,Qi, Ling Yan.,Chen, Song.,Cao, Lian Yuan.,...&Kosten, Thomas R..(2009).Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics.PSYCHOPHARMACOLOGY,204(1),177-184.
MLA Zhang, Xiang Yang,et al."Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics".PSYCHOPHARMACOLOGY 204.1(2009):177-184.
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