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学科主题: 临床医学
题名:
Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar
作者: Wen, Chi Pang1,2; Matsushita, Kunihiro3; Coresh, Josef3; Iseki, Kunitoshi4; Islam, Muhammad5; Katz, Ronit6; McClellan, William7; Peralta, Carmen A.8; Wang, HaiYan9; de Zeeuw, Dick10; Astor, Brad C.11,12; Gansevoort, Ron T.13; Levey, Andrew S.14; Levin, Adeera15; Chronic Kidney Dis Prognosis1
关键词: chronic kidney disease ; end-stage renal disease ; epidemiology and outcomes ; ethnicity ; mortality risk
刊名: KIDNEY INTERNATIONAL
发表日期: 2014-10-01
DOI: 10.1038/ki.2013.553
卷: 86, 期:4, 页:819-827
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; CKD-EPI EQUATION ; COLLABORATIVE METAANALYSIS ; POPULATION COHORTS ; HIGHER ALBUMINURIA ; ALL-CAUSE ; INDIVIDUALS ; ASSOCIATIONS ; PROTEINURIA ; PREVALENCE
英文摘要:

Some suggest race-specific cutpoints for kidney measures to define and stage chronic kidney disease (CKD), but evidence for race-specific clinical impact is limited. To address this issue, we compared hazard ratios of estimated glomerular filtration rates (eGFR) and albuminuria across races using meta-regression in 1.1 million adults (75% Asians, 21% Whites, and 4% Blacks) from 45 cohorts. Results came mainly from 25 general population cohorts comprising 0.9 million individuals. The associations of lower eGFR and higher albuminuria with mortality and end-stage renal disease (ESRD) were largely similar across races. For example, in Asians, Whites, and Blacks, the adjusted hazard ratios (95% confidence interval) for eGFR 45-59 versus 90-104 ml/min per 1.73 m(2) were 1.3 (1.2-1.3), 1.1 (1.0-1.2), and 1.3 (1.1-1.7) for all-cause mortality, 1.6 (1.5-1.7), 1.4 (1.2-1.7), and 1.4 (0.7-2.9) for cardiovascular mortality, and 27.6 (11.1-68.7), 11.2 (6.0-20.9), and 4.1 (2.2-7.5) for ESRD, respectively. The corresponding hazard ratios for urine albumin-to-creatinine ratio 30-299 mg/g or dipstick 1 + versus an albumin-to-creatinine ratio under 10 or dipstick negative were 1.6 (1.4-1.8), 1.7 (1.5-1.9), and 1.8 (1.7-2.1) for all-cause mortality, 1.7 (1.4-2.0), 1.8 (1.5-2.1), and 2.8 (2.2-3.6) for cardiovascular mortality, and 7.4 (2.0-27.6), 4.0 (2.8-5.9), and 5.6 (3.4-9.2) for ESRD, respectively. Thus, the relative mortality or ESRD risks of lower eGFR and higher albuminuria were largely similar among three major races, supporting similar clinical approach to CKD definition and staging, across races.

语种: 英语
WOS记录号: WOS:000342881000021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50794
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Emory Univ, Sch Med, Dept Med, Atlanta, GA USA
2.Aga Khan Univ, Dept Community Hlth Sci, Karachi, Pakistan
3.Univ Hosp Ryukyus, Dialysis Unit, Nishihara, Okinawa, Japan
4.Tufts Med Ctr, Div Nephrol, Boston, MA USA
5.Natl Hlth Res Inst, Inst Populat Sci, Zhunan, Taiwan
6.China Med Univ Hosp, Taichung, Taiwan
7.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
8.Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA
9.Univ Calif San Francisco, Div Nephrol, San Francisco, CA 94143 USA
10.Peking Univ, Key Lab Renal Dis, Minist Hlth China, Renal Div,Dept Med,Inst Nephrol,Hosp 1, Beijing, Peoples R China
11.Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharmacol, Groningen, Netherlands
12.Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI USA
13.Univ Wisconsin, Dept Populat Hlth Sci, Sch Med & Publ Hlth, Madison, WI USA
14.Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands
15.St Pauls Hosp, Div Nephrol UBC, Vancouver, BC V6Z 1Y6, Canada

Recommended Citation:
Wen, Chi Pang,Matsushita, Kunihiro,Coresh, Josef,et al. Relative risks of chronic kidney disease for mortality and end-stage renal disease across races are similar[J]. KIDNEY INTERNATIONAL,2014,86(4):819-827.
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