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学科主题基础医学
Comparison of immunogylobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS
Zhao, Jincun1; Wang, Wei1; Wang, Wenling1; Zhao, Zhendong1; Zhang, Yan1; Lv, Ping1; Ren, Furong1; Gao, Xiao-Ming1
刊名CLINICAL AND VACCINE IMMUNOLOGY
2007-07-01
DOI10.1128/CVI.00432-06
14期:7页:839-846
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]ANGIOTENSIN-CONVERTING ENZYME-2 ; FUNCTIONAL RECEPTOR ; GENOME SEQUENCE ; ANTIBODIES ; EXPRESSION ; VIRUS
英文摘要

Both the nucleocapsid (N) and the spike (S) proteins of severe acute respiratory syndrome (SARS)associated coronavirus (SARS-CoV) are able to induce strong humoral responses in humans following an infection. To compare the immunoglobulin G (IgG) responses to the S and N proteins of SARS-CoV in SARS patients during the manifestation/convalescent period with those during the postinfection period, serum samples were collected from hospitalized SARS patients within 6 weeks after the onset of illness (set 1; 57 sequential samples from 19 patients) or 2 to 3 months after their recovery (set 2; 33 postinfection samples from 33 subjects). Serum samples from 100 healthy blood donors (set 3), collected in 2002, were also included. The specific IgG response to whole virus, the fragment from positions 450 to 650 of the S protein (S450-650), and the full-length N protein of SARS-CoV were measured by enzyme-linked immunosorbent assays (ELISAs). Western blot assays were carried out to confirm the ELISA results. Fifty-one of the serum samples in set 1 (89%) bound to the N protein, a proportion similar to that which recognized whole virus (79%) and the S-protein fragment (77%). All 33 serum samples from set 2 were strongly positive for N-protein-specific IgG, while 27 (82%) were positive for anti-S450-650 IgG. Two of the serum samples from set 3 were strongly positive for anti-N-protein IgG but not anti-S450-650 IgG. Similar levels of IgG responses to the S and N proteins were observed in SARS patients during the manifestation and convalescent stages. In the postinfection period, however, a number of patients had much lower serum IgG levels against S450-650 than against the N protein.

语种英语
WOS记录号WOS:000248074800004
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50795
专题北京大学基础医学院_免疫学系
作者单位1.Beijing Red Cross Blood Ctr, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100093, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Jincun,Wang, Wei,Wang, Wenling,et al. Comparison of immunogylobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS[J]. CLINICAL AND VACCINE IMMUNOLOGY,2007,14(7):839-846.
APA Zhao, Jincun.,Wang, Wei.,Wang, Wenling.,Zhao, Zhendong.,Zhang, Yan.,...&Gao, Xiao-Ming.(2007).Comparison of immunogylobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS.CLINICAL AND VACCINE IMMUNOLOGY,14(7),839-846.
MLA Zhao, Jincun,et al."Comparison of immunogylobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS".CLINICAL AND VACCINE IMMUNOLOGY 14.7(2007):839-846.
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