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学科主题: 精神卫生
题名:
Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice
作者: Bi, Xiaoying2; Zhang, Yanbo1,3; Yan, Bin3; Fang, Shaokuan4; He, Jue1; Zhang, Dai5; Zhang, Zhijun6; Kong, Jiming7; Tan, Qingrong8; Li, Xin-Min1
关键词: cerebral ischemia ; hippocampus ; myelin ; oligodendrocyte ; quetiapine ; vascular depression
刊名: JOURNAL OF NEUROCHEMISTRY
发表日期: 2012-10-01
DOI: 10.1111/j.1471-4159.2012.07883.x
卷: 123, 期:1, 页:14-20
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: LATE-LIFE DEPRESSION ; BEHAVIORAL-CHANGES ; RAT-BRAIN ; REPERFUSION ; MOUSE ; DEATH
英文摘要:

White matter impairment is a feature of vascular depression. The anti-psychotic quetiapine has been shown to enhance the therapeutic effects of anti-depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti-depressant effects through white matter protection in vascular depression.

语种: 英语
所属项目编号: 2008087 ; 81101010
项目资助者: Canadian Institutes of Health Research (CIHR) China-Canada Collaborative Teams in Health Research ; CIHR Canada-China Joint Health Research Initiative program grant ; Shanghai Municipal Health Bureau general program ; National Natural Science Foundation of China ; AstraZeneca ; Pfizer
WOS记录号: WOS:000308631800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50802
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3E 3N4, Canada
2.Secondary Mil Med Univ, Shanghai Changhai Hosp, Dept Neurol, Shanghai, Peoples R China
3.Univ Saskatchewan, Dept Psychiat, Coll Med, Saskatoon, SK S7N 0W0, Canada
4.Jilin Univ, Dept Neurol, Hosp 1, Changchun 130023, Jilin, Peoples R China
5.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
6.Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China
7.Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 3N4, Canada
8.Fourth Mil Med Univ, Dept Psychiat, Xijing Hosp, Xian 710032, Shanxi, Peoples R China

Recommended Citation:
Bi, Xiaoying,Zhang, Yanbo,Yan, Bin,et al. Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice[J]. JOURNAL OF NEUROCHEMISTRY,2012,123(1):14-20.
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