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Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice
Bi, Xiaoying2; Zhang, Yanbo1,3; Yan, Bin3; Fang, Shaokuan4; He, Jue1; Zhang, Dai5; Zhang, Zhijun6; Kong, Jiming7; Tan, Qingrong8; Li, Xin-Min1
关键词Cerebral Ischemia Hippocampus Myelin Oligodendrocyte Quetiapine Vascular Depression
刊名JOURNAL OF NEUROCHEMISTRY
2012-10-01
DOI10.1111/j.1471-4159.2012.07883.x
123期:1页:14-20
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
资助者Canadian Institutes of Health Research (CIHR) China-Canada Collaborative Teams in Health Research ; CIHR Canada-China Joint Health Research Initiative program grant ; Shanghai Municipal Health Bureau general program ; National Natural Science Foundation of China ; AstraZeneca ; Pfizer ; Canadian Institutes of Health Research (CIHR) China-Canada Collaborative Teams in Health Research ; CIHR Canada-China Joint Health Research Initiative program grant ; Shanghai Municipal Health Bureau general program ; National Natural Science Foundation of China ; AstraZeneca ; Pfizer
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]LATE-LIFE DEPRESSION ; BEHAVIORAL-CHANGES ; RAT-BRAIN ; REPERFUSION ; MOUSE ; DEATH
英文摘要

White matter impairment is a feature of vascular depression. The anti-psychotic quetiapine has been shown to enhance the therapeutic effects of anti-depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti-depressant effects through white matter protection in vascular depression.

语种英语
所属项目编号2008087 ; 81101010
资助者Canadian Institutes of Health Research (CIHR) China-Canada Collaborative Teams in Health Research ; CIHR Canada-China Joint Health Research Initiative program grant ; Shanghai Municipal Health Bureau general program ; National Natural Science Foundation of China ; AstraZeneca ; Pfizer ; Canadian Institutes of Health Research (CIHR) China-Canada Collaborative Teams in Health Research ; CIHR Canada-China Joint Health Research Initiative program grant ; Shanghai Municipal Health Bureau general program ; National Natural Science Foundation of China ; AstraZeneca ; Pfizer
WOS记录号WOS:000308631800002
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50802
专题北京大学精神卫生研究所
作者单位1.Univ Manitoba, Dept Psychiat, Fac Med, Winnipeg, MB R3E 3N4, Canada
2.Secondary Mil Med Univ, Shanghai Changhai Hosp, Dept Neurol, Shanghai, Peoples R China
3.Univ Saskatchewan, Dept Psychiat, Coll Med, Saskatoon, SK S7N 0W0, Canada
4.Jilin Univ, Dept Neurol, Hosp 1, Changchun 130023, Jilin, Peoples R China
5.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
6.Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China
7.Univ Manitoba, Fac Med, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 3N4, Canada
8.Fourth Mil Med Univ, Dept Psychiat, Xijing Hosp, Xian 710032, Shanxi, Peoples R China
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GB/T 7714
Bi, Xiaoying,Zhang, Yanbo,Yan, Bin,et al. Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice[J]. JOURNAL OF NEUROCHEMISTRY,2012,123(1):14-20.
APA Bi, Xiaoying.,Zhang, Yanbo.,Yan, Bin.,Fang, Shaokuan.,He, Jue.,...&Li, Xin-Min.(2012).Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice.JOURNAL OF NEUROCHEMISTRY,123(1),14-20.
MLA Bi, Xiaoying,et al."Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice".JOURNAL OF NEUROCHEMISTRY 123.1(2012):14-20.
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