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学科主题: 口腔医学
题名:
Bmp2 and Bmp4 accelerate alveolar bone development
作者: Ou, Mingming1; Zhao, Yibing2; Zhang, Fangming1; Huang, Xiaofeng1,3
关键词: Alveolar bone ; bone morphogenetic proteins ; dental follicle ; periodontal tissue ; tooth
刊名: CONNECTIVE TISSUE RESEARCH
发表日期: 2015-06-01
DOI: 10.3109/03008207.2014.996701
卷: 56, 期:3, 页:204-211
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Orthopedics
研究领域[WOS]: Cell Biology ; Orthopedics
关键词[WOS]: TOOTH ROOT DEVELOPMENT ; MORPHOGENETIC PROTEIN-2 ; DENTAL FOLLICLE ; STEM-CELLS ; EXPRESSION ; DIFFERENTIATION ; PERIODONTIUM ; REGENERATION ; INDUCTION ; MOVEMENT
英文摘要:

Alveolar bone remodeling is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. Mice at embryonic (E) day 13.5 to postnatal (PN) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from mice at PN7.5 were pretreated with Bmp2, Bmp4, Noggin, or BSA, and grafted subcutaneously into mice. The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with Bmp2 and Bmp4, but not with Noggin. Gene expression levels in dental follicle cells from murine molars were also determined by real-time RT-PCR. The expression levels of Runx2, Bsp, and Ocn were significantly higher in dental follicle cells cultured with Bmp2 or Bmp4, and significantly lower in those cultured with Noggin when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and Bmp2/4 appears to accelerate alveolar bone development.

语种: 英语
所属项目编号: 81170943 ; 7122051 ; 92897 ; 2011-3-008
项目资助者: National Natural Science Foundation in China ; Beijing Natural Science Foundation ; SRF for ROCS, SEM ; Beijing high-level personnel training programs of the health system
WOS记录号: WOS:000354314900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50803
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Capital Med Univ, Dept Stomatol, Beijing Friendship Hosp, Beijing 100050, Peoples R China
2.Peking Univ, Dept Periodontol, Sch Stomatol, Beijing 100871, Peoples R China
3.Capital Med Univ, Beijng Key Lab Tooth Regenerat & Funct Reconstruc, Beijing, Peoples R China

Recommended Citation:
Ou, Mingming,Zhao, Yibing,Zhang, Fangming,et al. Bmp2 and Bmp4 accelerate alveolar bone development[J]. CONNECTIVE TISSUE RESEARCH,2015,56(3):204-211.
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