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Quantitative high-performance liquid chromatographic analysis of nitroxoline and structurally related compounds
Kang, XJ1; Wan, ZY1
关键词Column Liquid Chromatography Nitroxoline 8-hydroxyquine Plasma And Urine 8-hydroxy-5-nitrosoquinoline And 8-hydroxy-5 7-dinitroquinoline
刊名CHROMATOGRAPHIA
2003-03-01
57期:5-6页:405-408
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
英文摘要

Nitroxoline (8-hydroxy-5-nitroquinoline) and the structural related compounds 8-hydroxyquine, 8-hydroxy-5,7-dinitroquinoline, and 8-hydroxy-5-nitrosoquinoline have been investigated by reversed-phase high-performance liquid chromatography on C-18/ODS. Complete separation and symmetric peaks were obtained by use of THF-methanol-water, 3:14, containing 10 mmol L-1 disodium ethylenediamine tetraacetic acid (EDTA) and 10 mmol L-1 citric acid in the water, as mobile phase. The pH and the concentration of EDTA in the mobile phase were found to be critical for eliminating tailing and for full separation. The calibration plot was linear for concentrations between 3.0 and 300 mug mL(-1); the regression coefficient was 0.99996. Assay of the nitroxoline standard showed that recovery was from 99.3 to 102%, with a mean standard deviation for nitroxoline of 0.9%. The method is suitable for quality control of nitroxoline.

语种英语
WOS记录号WOS:000181845100020
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50807
专题北京大学药学院_药剂学系
作者单位1.Southeast Univ, Coll Publ Hlth, Nanjing 210009, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Kang, XJ,Wan, ZY. Quantitative high-performance liquid chromatographic analysis of nitroxoline and structurally related compounds[J]. CHROMATOGRAPHIA,2003,57(5-6):405-408.
APA Kang, XJ,&Wan, ZY.(2003).Quantitative high-performance liquid chromatographic analysis of nitroxoline and structurally related compounds.CHROMATOGRAPHIA,57(5-6),405-408.
MLA Kang, XJ,et al."Quantitative high-performance liquid chromatographic analysis of nitroxoline and structurally related compounds".CHROMATOGRAPHIA 57.5-6(2003):405-408.
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