北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
Quantitative high-performance liquid chromatographic analysis of nitroxoline and structurally related compounds
作者: Kang, XJ1; Wan, ZY1
关键词: column liquid chromatography ; nitroxoline ; 8-hydroxyquine ; 8-Hydroxy-5-nitrosoquinoline and 8-hydroxy-5,7-dinitroquinoline ; plasma and urine
刊名: CHROMATOGRAPHIA
发表日期: 2003-03-01
卷: 57, 期:5-6, 页:405-408
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
英文摘要:

Nitroxoline (8-hydroxy-5-nitroquinoline) and the structural related compounds 8-hydroxyquine, 8-hydroxy-5,7-dinitroquinoline, and 8-hydroxy-5-nitrosoquinoline have been investigated by reversed-phase high-performance liquid chromatography on C-18/ODS. Complete separation and symmetric peaks were obtained by use of THF-methanol-water, 3:14, containing 10 mmol L-1 disodium ethylenediamine tetraacetic acid (EDTA) and 10 mmol L-1 citric acid in the water, as mobile phase. The pH and the concentration of EDTA in the mobile phase were found to be critical for eliminating tailing and for full separation. The calibration plot was linear for concentrations between 3.0 and 300 mug mL(-1); the regression coefficient was 0.99996. Assay of the nitroxoline standard showed that recovery was from 99.3 to 102%, with a mean standard deviation for nitroxoline of 0.9%. The method is suitable for quality control of nitroxoline.

语种: 英语
WOS记录号: WOS:000181845100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50807
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Southeast Univ, Coll Publ Hlth, Nanjing 210009, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Kang, XJ,Wan, ZY. Quantitative high-performance liquid chromatographic analysis of nitroxoline and structurally related compounds[J]. CHROMATOGRAPHIA,2003,57(5-6):405-408.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Kang, XJ]'s Articles
[Wan, ZY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Kang, XJ]‘s Articles
[Wan, ZY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace