IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Plasma levels and diagnostic value of catestatin in patients with heart failure
Liu, Lin; Ding, Wenhui; Li, Renxu; Ye, Xiaojin; Zhao, Jing; Jiang, Jie; Meng, Lei; Wang, Jie; Chu, Songyun; Han, Xiaoning; Peng, Fen
关键词Catestatin Heart Failure Neuroendocrine Biomarker
刊名PEPTIDES
2013-08-01
DOI10.1016/j.peptides.2013.05.003
46页:20-25
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]CHROMOGRANIN-A FRAGMENT ; PEPTIDE CATESTATIN ; IN-VIVO ; CATECHOLAMINE RELEASE ; CARDIAC-FUNCTION ; DISEASE ; INHIBITION ; A(344-364) ; ACTS
英文摘要

Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patients and 172 controls. Plasma CST gradually increased in patients from NYHA class I to class IV. No significant differences in CST were found among NYHA I, NYHA II patients and controls. Plasma CST in NYHA III and IV patients was higher compared to other groups. Plasma CST levels in HF patients after treatment were similar to admission, but still higher than controls. In a subgroup analysis among the patients with NYHA class III or IV, patients with ischemic etiology had significantly higher CST. Plasma CST levels were similar between patients with preserved and reduced ejection fraction. Multivariable analysis showed that NYHA classes, the etiology of HF (ischemic or not) and estimated glomerular filtration rate independently predicted plasma LogCST levels (P < 0.05). The area under ROC for CST and BNP in moderate to severe HF diagnosis was 0.626 and 0.831, respectively, combining CST and BNP did not improve the accuracy. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000322628600004
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50811
Collection北京大学第一临床医学院_心血管内科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Liu, Lin,Ding, Wenhui,Li, Renxu,et al. Plasma levels and diagnostic value of catestatin in patients with heart failure[J]. PEPTIDES,2013,46:20-25.
APA Liu, Lin.,Ding, Wenhui.,Li, Renxu.,Ye, Xiaojin.,Zhao, Jing.,...&Peng, Fen.(2013).Plasma levels and diagnostic value of catestatin in patients with heart failure.PEPTIDES,46,20-25.
MLA Liu, Lin,et al."Plasma levels and diagnostic value of catestatin in patients with heart failure".PEPTIDES 46(2013):20-25.
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