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学科主题: 临床医学
题名:
Plasma levels and diagnostic value of catestatin in patients with heart failure
作者: Liu, Lin; Ding, Wenhui; Li, Renxu; Ye, Xiaojin; Zhao, Jing; Jiang, Jie; Meng, Lei; Wang, Jie; Chu, Songyun; Han, Xiaoning; Peng, Fen
关键词: Catestatin ; Heart failure ; Neuroendocrine ; Biomarker
刊名: PEPTIDES
发表日期: 2013-08-01
DOI: 10.1016/j.peptides.2013.05.003
卷: 46, 页:20-25
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: CHROMOGRANIN-A FRAGMENT ; PEPTIDE CATESTATIN ; IN-VIVO ; CATECHOLAMINE RELEASE ; CARDIAC-FUNCTION ; DISEASE ; INHIBITION ; A(344-364) ; ACTS
英文摘要:

Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patients and 172 controls. Plasma CST gradually increased in patients from NYHA class I to class IV. No significant differences in CST were found among NYHA I, NYHA II patients and controls. Plasma CST in NYHA III and IV patients was higher compared to other groups. Plasma CST levels in HF patients after treatment were similar to admission, but still higher than controls. In a subgroup analysis among the patients with NYHA class III or IV, patients with ischemic etiology had significantly higher CST. Plasma CST levels were similar between patients with preserved and reduced ejection fraction. Multivariable analysis showed that NYHA classes, the etiology of HF (ischemic or not) and estimated glomerular filtration rate independently predicted plasma LogCST levels (P < 0.05). The area under ROC for CST and BNP in moderate to severe HF diagnosis was 0.626 and 0.831, respectively, combining CST and BNP did not improve the accuracy. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2009-3026 ; 20100001120136
项目资助者: Medical Development of the Capital ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000322628600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50811
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Lin,Ding, Wenhui,Li, Renxu,et al. Plasma levels and diagnostic value of catestatin in patients with heart failure[J]. PEPTIDES,2013,46:20-25.
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