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学科主题: 精神卫生
题名:
Brain Correlates of Self-Evaluation Deficits in Schizophrenia: A Combined Functional and Structural MRI Study
作者: Tan, Shuping1,2; Zhao, Yanli2; Fan, Fengmei2; Zou, Yizhuang2; Jin, Zhen3; Zen, Yawei3; Zhu, Xiaolin2; Yang, Fude2; Tan, Yunlong2; Zhou, Dongfeng1
刊名: PLOS ONE
发表日期: 2015-09-25
DOI: 10.1371/journal.pone.0138737
卷: 10, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ANTERIOR CINGULATE CORTEX ; FMRI ; REFLECTION ; AWARENESS ; METAANALYSIS ; ACTIVATION ; INSIGHT
英文摘要:

Self-evaluation plays an important role in adaptive functioning and is a process that is typically impaired in patients with schizophrenia. Underlying neural mechanisms for this dysfunction may be associated with manifested psychosis. However, the brain substrates underlying this deficit are not well known. The present study used brain blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) and gray matter voxel-based morphometry to explore the functional and structural brain correlates of self-evaluation deficits in schizophrenia. Eighteen patients with schizophrenia and 17 healthy controls were recruited and asked to judge whether a set of personality-trait adjectives were appropriate for describing themselves, a familiar other, or whether the adjectives were of positive or negative valence. Patients had slower response times for negative trait attributions than controls did; responses to positive trait attributions were faster than those for negative traits among the patient group, while no differences were observed in the control group. Control subjects showed greater activation within the dorsal medial prefrontal cortex (dMPFC) and the anterior cingulate cortex (ACC) than the patient group during the self-evaluation > semantic positivity-evaluation contrast. Patients showed greater activation mainly within the posterior cingulate gyrus (PCC) as compared to controls for the other-evaluation > semantic positivity-evaluation contrast. Furthermore, gray matter volume was reduced in the MPFC, temporal lobe, cuneus, and the dorsal lateral prefrontal cortex (DLPFC) among the patient group when compared to controls. The present study adds to previous findings regarding self-and other-referential processing in schizophrenia, providing support for neurobiological models of self-reflection impairment.

语种: 英语
所属项目编号: 2011-2013-02 ; Z141107002514016 ; D121100005012005 ; 81461130016 ; zy201409 ; 81401133
项目资助者: Fund of Capital Medical Development and Research grant ; Beijing Municipal Science &amp ; Technology Commission ; International Cooperation and Exchange of the National Natural Science Foundation of China ; Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding ; National Natural Science Foundation of China
WOS记录号: WOS:000361800700080
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50812
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China
3.306th Hosp PLA, Magnet Res Imaging Unit, Beijing 100101, Peoples R China

Recommended Citation:
Tan, Shuping,Zhao, Yanli,Fan, Fengmei,et al. Brain Correlates of Self-Evaluation Deficits in Schizophrenia: A Combined Functional and Structural MRI Study[J]. PLOS ONE,2015,10(9).
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