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学科主题: 精神卫生
题名:
QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009
作者: Xiang, Yu-Tao1,2; Chiu, Helen F. K.2; Ungvari, Gabor S.3; Correll, Christoph U.4; Lai, Kelly Y. C.2; Wang, Chuan-Yue5; Si, Tian-Mei6,7; Lee, Edwin H. M.8; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.15; Trivedi, Jitendra K.16; Chung, Eun-Kee17; Udomratn, Pichet18; Chee, Kok-Yoon19; Sartorius, Norman20; Tan, Chay-Hoon21; Shinfuku, Naotaka22
关键词: Schizophrenia ; QTc prolongation ; inpatients ; Asia
刊名: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
发表日期: 2015-03-01
DOI: 10.1002/hup.2458
卷: 30, 期:2, 页:94-99
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
关键词[WOS]: ATYPICAL ANTIPSYCHOTICS ; DRUGS ; INPATIENTS ; INTERVAL
英文摘要:

ObjectiveLittle is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates.

MethodData on 3482 hospitalized schizophrenia patients (2004=1826 and 2008/2009=1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients′ sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure.

ResultsThe frequency of QTc prolongation (>456ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p=0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values<0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95% CI 1.3-4.5), clozapine (OR 2.4; 95% CI 1.4-4.2), and chlorpromazine (OR 1.9; 95% CI 1.07-3.5).

ConclusionsFrequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries. Copyright (c) 2015 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Natural Science Foundation of China ; Beijing Nova Program of the Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health Research in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
WOS记录号: WOS:000351400900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50818
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
3.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Taipei City Hosp, Taipei, Taiwan
5.Chang Gung Univ, Sch Med, Gueishan, Taiwan
6.Fukushima Med Univ, Fukushima, Japan
7.Inst Mental Hlth, Buangkok, Singapore
8.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
9.Natl Seoul Hosp, Dept Psychiat, Seoul, South Korea
10.Associat Improvement Mental Hlth Programs, Geneva, Switzerland
11.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
12.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
13.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
14.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
15.Zucker Hillside Hosp, Div Psychiat Res, North Shore Long Isl Jewish Hlth Syst, Glen Oaks, NY USA
16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
17.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
18.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Gueishan, Taiwan
19.Natl Univ Singapore, Dept Psychol Med, Singapore 117548, Singapore
20.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
21.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
22.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore

Recommended Citation:
Xiang, Yu-Tao,Chiu, Helen F. K.,Ungvari, Gabor S.,et al. QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2015,30(2):94-99.
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