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QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009
Xiang, Yu-Tao1,2; Chiu, Helen F. K.2; Ungvari, Gabor S.3; Correll, Christoph U.4; Lai, Kelly Y. C.2; Wang, Chuan-Yue5; Si, Tian-Mei6,7; Lee, Edwin H. M.8; He, Yan-Ling9; Yang, Shu-Yu10; Chong, Mian-Yoon11,12; Kua, Ee-Heok13; Fujii, Senta14; Sim, Kang15; Yong, Michael K. H.15; Trivedi, Jitendra K.16; Chung, Eun-Kee17; Udomratn, Pichet18; Chee, Kok-Yoon19; Sartorius, Norman20; Tan, Chay-Hoon21; Shinfuku, Naotaka22
关键词Schizophrenia Qtc Prolongation Inpatients Asia
刊名HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
2015-03-01
DOI10.1002/hup.2458
30期:2页:94-99
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology ; Social Sciences
类目[WOS]Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
关键词[WOS]ATYPICAL ANTIPSYCHOTICS ; DRUGS ; INPATIENTS ; INTERVAL
英文摘要

ObjectiveLittle is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates.

MethodData on 3482 hospitalized schizophrenia patients (2004=1826 and 2008/2009=1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients′ sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure.

ResultsThe frequency of QTc prolongation (>456ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p=0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values<0.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5years and received antipsychotics classified as list-1 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2-15.2), followed by sulpiride (OR 2.4; 95% CI 1.3-4.5), clozapine (OR 2.4; 95% CI 1.4-4.2), and chlorpromazine (OR 1.9; 95% CI 1.07-3.5).

ConclusionsFrequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008/2009 but increased in Taiwan over the same period, remaining low in the other countries. Copyright (c) 2015 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000351400900004
项目编号81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Natural Science Foundation of China ; Beijing Nova Program of the Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health Research in Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government in Taiwan
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50818
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Seinan Gakuin Univ Fukuoka, Sch Human Sci, Fukuoka, Japan
3.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
4.Taipei City Hosp, Taipei, Taiwan
5.Chang Gung Univ, Sch Med, Gueishan, Taiwan
6.Fukushima Med Univ, Fukushima, Japan
7.Inst Mental Hlth, Buangkok, Singapore
8.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
9.Natl Seoul Hosp, Dept Psychiat, Seoul, South Korea
10.Associat Improvement Mental Hlth Programs, Geneva, Switzerland
11.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
12.Minist Mental Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
13.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
14.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
15.Zucker Hillside Hosp, Div Psychiat Res, North Shore Long Isl Jewish Hlth Syst, Glen Oaks, NY USA
16.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
17.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
18.Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Gueishan, Taiwan
19.Natl Univ Singapore, Dept Psychol Med, Singapore 117548, Singapore
20.Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
21.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
22.Natl Univ Singapore, Dept Pharmacol, Singapore 117548, Singapore
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GB/T 7714
Xiang, Yu-Tao,Chiu, Helen F. K.,Ungvari, Gabor S.,et al. QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2015,30(2):94-99.
APA Xiang, Yu-Tao.,Chiu, Helen F. K..,Ungvari, Gabor S..,Correll, Christoph U..,Lai, Kelly Y. C..,...&Shinfuku, Naotaka.(2015).QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,30(2),94-99.
MLA Xiang, Yu-Tao,et al."QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 30.2(2015):94-99.
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